| Gene Symbol |
DCP1A
|
| Entrez Gene |
55802
|
| Alt Symbol |
HSA275986, Nbla00360, SMAD4IP1, SMIF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
decapping mRNA 1A
|
| Other Description |
DCP1 decapping enzyme homolog A|Smad4-interacting transcriptional co-activator|decapping enzyme hDcp1a|mRNA-decapping enzyme 1A|putative protein product of Nbla00360|transcription factor SMIF
|
| Swissprots |
B4DHN9 U3KQM8 Q9NPI6
|
| Accessions |
EAW65283 EAW65284 Q9NPI6 AA129009 AB075507 BAE45754 AJ275986 CAB77023 AK001969 BAA92008 AK025344 AK094470 AK295205 BAG58201 AY146651 AAN62763 BC007439 AAH07439 BC016729 BI769171 BM016520 BP284272 BX481349 CA407150 CD676826 CN289842 DA568874 DA786683 DC371232 DQ893260 ABM84186 DQ896589 ABM87588 NM_001290204 NP_001277133 NM_001290205 NP_001277134 NM_001290206 NP_001277135 NM_001290207 NP_001277136 NM_018403 NP_060873
|
| Function |
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715}.
|
| Subcellular Location |
Cytoplasm, P-body. Nucleus. Note=Co- localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4. {ECO:0000250}.
|
| Tissue Specificity |
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. {ECO:0000269|PubMed:11836524}.
|
| Top Pathways |
RNA degradation
|
![Western Blot: Dcp1a Overexpression Lysate (Adult Normal) [NBL1-09745] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dcp1a.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3317_Dcp1a%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09745-img0002.jpg)