DCP1A

Gene Symbol	DCP1A
Entrez Gene	55802
Alt Symbol	HSA275986, Nbla00360, SMAD4IP1, SMIF
Species	Human
Gene Type	protein-coding
Description	decapping mRNA 1A
Other Description	DCP1 decapping enzyme homolog A\|Smad4-interacting transcriptional co-activator\|decapping enzyme hDcp1a\|mRNA-decapping enzyme 1A\|putative protein product of Nbla00360\|transcription factor SMIF
Swissprots	B4DHN9 U3KQM8 Q9NPI6
Accessions	EAW65283 EAW65284 Q9NPI6 AA129009 AB075507 BAE45754 AJ275986 CAB77023 AK001969 BAA92008 AK025344 AK094470 AK295205 BAG58201 AY146651 AAN62763 BC007439 AAH07439 BC016729 BI769171 BM016520 BP284272 BX481349 CA407150 CD676826 CN289842 DA568874 DA786683 DC371232 DQ893260 ABM84186 DQ896589 ABM87588 NM_001290204 NP_001277133 NM_001290205 NP_001277134 NM_001290206 NP_001277135 NM_001290207 NP_001277136 NM_018403 NP_060873
Function	Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. {ECO:0000269\|PubMed:11836524, ECO:0000269\|PubMed:12417715}.
Subcellular Location	Cytoplasm, P-body. Nucleus. Note=Co- localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4. {ECO:0000250}.
Tissue Specificity	Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. {ECO:0000269\|PubMed:11836524}.
Top Pathways	RNA degradation

Dcp1a (C-14) - sc-34909 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Dcp1a (C-17) - sc-22575 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

hDcp1a (C-17): sc-22575. Western blot analysis of hDcp1a expression in mouse brain tissue extract.

Dcp1a (D-13) - sc-22574 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

hDcp1a (D-13): sc-22574. Western blot analysis of hDcp1a expression in mouse brain tissue extract.

Dcp1a (G-15) - sc-34910 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

hDcp1a (G-15): sc-34910. Western blot analysis of hDcp1a expression in IMR-32 whole cell lysate (A) and rat brain tissue extract (B).

Dcp1a (56-Y) - sc-100706 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

Dcp1a (56-Y): sc-100706. Western blot analysis of Dcp1a expression in IMR-32 whole cell lysate.

Anti-Dcp1a antibody - ab47811 from Abcam

Prices	$400.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC image of Dcp1a staining in human placenta formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab47811, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Dcp1a antibody - ab57654 from Abcam

Prices	$382.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-Dcp1a antibody - ab66009 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Dcp1a antibody (ab66009) at 1/500 dilutionLane 1 : Jurkat cell extractsLane 2 : Jurkat cell extracts with immunising peptide at 10 µgLysates/proteins at 10 µg per lane.

Anti-Dcp1a antibody - ab47998 from Abcam

Prices	$376.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

Anti-Dcp1a antibody (ab47998) at 2 µg/ml + A431 cell lysate in RIPA buffer at 35 µg

Anti-Dcp1a antibody - ab128156 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Dcp1a antibody (ab128156) at 0.4 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-Dcp1a antibody - ab128169 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Dcp1a antibody (ab128169) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-Dcp1a antibody - ab128176 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Dcp1a antibody (ab128176) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-Dcp1a antibody [EPR13822] - ab183709 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR13822

Anti-Dcp1a antibody [EPR13822] (ab183709) at 1/10000 dilution + 293T cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-SMIF / DCP1A Antibody (N-Terminus) - LS-C31218 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SMIF / DCP1A Antibody (aa199-248) - LS-C31219 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SMIF / DCP1A Antibody (clone 2G10) - LS-C139418 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2G10

DCP1A monoclonal antibody (M07), clone 2G10. Western blot of DCP1A expression in IMR-32.

Anti-SMIF / DCP1A Antibody (aa111-160) - LS-C119277 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from Jurkat cells, using DCP1A Antibody. The lane on the right is treated with the synthesized peptide.

Anti-SMIF / DCP1A Antibody (aa146-175, APC) - LS-C255926 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMIF / DCP1A Antibody (aa146-175, AP) - LS-C255927 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMIF / DCP1A Antibody (clone 2F11) - LS-C139419 from LifeSpan Bioscience

Prices	$355.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2F11

DCP1A monoclonal antibody (M02), clone 2F11. Western blot of DCP1A expression in IMR-32.

Anti-SMIF / DCP1A Antibody (aa571-581) - LS-C54709 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Antibody (2 ug/ml) staining of A431 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SMIF / DCP1A Antibody - LS-C136939 from LifeSpan Bioscience

Prices	$255.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMIF / DCP1A Antibody (aa146-175, Biotin) - LS-C255929 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMIF / DCP1A Antibody (Ser133) - LS-C176835 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of SMIF (S133) pAb in extracts from Jurkat cells.

Anti-SMIF / DCP1A Antibody (aa146-175, FITC) - LS-C255930 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

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