PATL1

Gene Symbol PATL1
Entrez Gene 219988
Alt Symbol Pat1b, hPat1b
Species Human
Gene Type protein-coding
Description protein associated with topoisomerase II homolog 1 (yeast)
Other Description PAT1-like protein 1|protein PAT1 homolog 1|protein PAT1 homolog b
Swissprots Q2TA86 Q6P166 B3KXT9 Q86TB9 Q8N9M6 Q8NI63
Accessions EAW73850 EAW73851 Q86TB9 AB065087 BAB93524 AK094193 BAC04305 AK127649 BAG54542 AK127943 BAG54601 AK293213 BAH11469 AL831992 CAD89916 AM392959 CAL37837 BC023255 BC048309 BC065264 AAH65264 BC109038 AAI09039 BC109039 AAI09040 BC111047 AAI11048 DC409866 XM_005273833 XP_005273890 XM_005273834 XP_005273891 XM_005273835 XP_005273892 XM_011544811 XP_011543113 NM_152716 NP_689929
Function RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:19628699, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.
Subcellular Location Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:17936923}.
Top Pathways RNA degradation

PATL1/PAT1b (D8P1B) Rabbit mAb - 14288 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8P1B
Western blot analysis of extracts from various cell lines using PATL1/PAT1b (D8P1B) Rabbit mAb.

PATL1 (S-16) - sc-168907 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PATL1 antibody - ab122526 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122526, at a 1/60 dilution, staining PATL1 in paraffin embedded Human colon tissue by Immunohistochemistry.

Anti-PATL1 antibody - ab124257 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PATL1 antibody (ab124257) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-PATL1 antibody - ab176729 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of immunoprecipitates, HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) labeling PATL1 using ab176729 at 1 µg/ml, with chemiluminescence detection with an exposure time of 30 seconds.

Anti-PATL1 Antibody (aa489-518) - LS-C163381 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PATL1 Antibody IHC of formalin-fixed and paraffin-embedded skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PATL1 Antibody (aa496-526, FITC) - LS-C265639 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PATL1 Antibody (aa496-526, Biotin) - LS-C265641 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PATL1 Antibody (aa496-526, Azide-free, HRP) - LS-C265643 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PATL1 Antibody (aa496-526, PE) - LS-C265644 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PATL1 Antibody (aa496-526, AP) - LS-C284485 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PATL1 Antibody (aa496-526, APC) - LS-C284486 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PATL1 Antibody (aa425-475) - LS-C290154 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PATL1 Antibody (aa550-600) - LS-C290155 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PATL1 Antibody (aa489-518) - LS-C323804 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

PATL1 Antibody - NBP1-93808 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PATL1 Antibody [NBP1-93808] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Anti-PATL1 antibody produced in rabbit - HPA039030 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PATL1: <B>Cat. No. HPA039030</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

ANTI-PATL1 (C-TERM) antibody produced in rabbit - SAB1303165 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>PATL1 (C-term): <B>Cat. No. SAB1303165</B>: PATL1 in Human skeletal muscle tissue with PATL1 antibody (C-term) at 5 μg/mL.

PATL1-Antibody-C-term - AP9796b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of PATL1 Antibody (C-term) (Cat. #AP9796b) in HL-60 cell line lysates (35ug/lane). PATL1 (arrow) was detected using the purified Pab.

PATL1 Antibody - C-terminal region (OAAB06397) - OAAB06397 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PATL1 (C-term) antibody - AP53172PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis in formalin fixed and paraffin embedded skeletal muscle reacted with PATL1 Antibody (C-term) Cat.-No AP53172PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. This data demonstrates the use of the PATL1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

PATL1 antibody - H00219988-B01P from Acris Antibodies

Prices $1,530.00
Sizes 500 µg
Host Mouse
Clonality Polyclonal

Anti-PATL1 (aa 550-600) polyclonal antibody - DPABH-12082 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-PATL1 (aa 360-457) polyclonal antibody - DPABH-20830 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Rabbit anti-Human PATL1 polyclonal antibody - DPABH-21923 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal
Search more