| Gene Symbol |
PATL1
|
| Entrez Gene |
219988
|
| Alt Symbol |
Pat1b, hPat1b
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein associated with topoisomerase II homolog 1 (yeast)
|
| Other Description |
PAT1-like protein 1|protein PAT1 homolog 1|protein PAT1 homolog b
|
| Swissprots |
Q2TA86 Q6P166 B3KXT9 Q86TB9 Q8N9M6 Q8NI63
|
| Accessions |
EAW73850 EAW73851 Q86TB9 AB065087 BAB93524 AK094193 BAC04305 AK127649 BAG54542 AK127943 BAG54601 AK293213 BAH11469 AL831992 CAD89916 AM392959 CAL37837 BC023255 BC048309 BC065264 AAH65264 BC109038 AAI09039 BC109039 AAI09040 BC111047 AAI11048 DC409866 XM_005273833 XP_005273890 XM_005273834 XP_005273891 XM_005273835 XP_005273892 XM_011544811 XP_011543113 NM_152716 NP_689929
|
| Function |
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:19628699, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.
|
| Subcellular Location |
Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:17936923}.
|
| Top Pathways |
RNA degradation
|