PATL1

Gene Symbol PATL1
Entrez Gene 219988
Alt Symbol Pat1b, hPat1b
Species Human
Gene Type protein-coding
Description protein associated with topoisomerase II homolog 1 (yeast)
Other Description PAT1-like protein 1|protein PAT1 homolog 1|protein PAT1 homolog b
Swissprots Q2TA86 Q6P166 B3KXT9 Q86TB9 Q8N9M6 Q8NI63
Accessions EAW73850 EAW73851 Q86TB9 AB065087 BAB93524 AK094193 BAC04305 AK127649 BAG54542 AK127943 BAG54601 AK293213 BAH11469 AL831992 CAD89916 AM392959 CAL37837 BC023255 BC048309 BC065264 AAH65264 BC109038 AAI09039 BC109039 AAI09040 BC111047 AAI11048 DC409866 XM_005273833 XP_005273890 XM_005273834 XP_005273891 XM_005273835 XP_005273892 XM_011544811 XP_011543113 NM_152716 NP_689929
Function RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:19628699, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.
Subcellular Location Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:17936923}.
Top Pathways RNA degradation

PATL1 CRISPR/Cas9 KO Plasmid (h) - sc-415098 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PATL1 HDR Plasmid (h) - sc-415098-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PATL1 Double Nickase Plasmid (h) - sc-415098-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PATL1 Double Nickase Plasmid (h2) - sc-415098-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PATL1 CRISPR Activation Plasmid (h) - sc-415098-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PATL1 CRISPR Activation Plasmid (h2) - sc-415098-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PATL1 Lentiviral Activation Particles (h) - sc-415098-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PATL1 Lentiviral Activation Particles (h2) - sc-415098-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PATL1 siRNA (h) - sc-96855 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PATL1 shRNA Plasmid (h) - sc-96855-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PATL1 shRNA (h) Lentiviral Particles - sc-96855-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN16365 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16365 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09850 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09850

PATL1 siRNA (Human) - CRJ6444 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PATL1 (NM_152716.2) - SHH371064 from Creative biogene

Category siRNA
Species Reactivities Human

Human PATL1 siRNA - orb276945 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PATL1 shRNA Plasmid (Human) - CHJ6444 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PATL1 miRNA 3'UTR clone - MiUTR3H-13345 from Creative biogene

Species Reactivities Human
Search more