PATL1

Gene Symbol PATL1
Entrez Gene 219988
Alt Symbol Pat1b, hPat1b
Species Human
Gene Type protein-coding
Description protein associated with topoisomerase II homolog 1 (yeast)
Other Description PAT1-like protein 1|protein PAT1 homolog 1|protein PAT1 homolog b
Swissprots Q2TA86 Q6P166 B3KXT9 Q86TB9 Q8N9M6 Q8NI63
Accessions EAW73850 EAW73851 Q86TB9 AB065087 BAB93524 AK094193 BAC04305 AK127649 BAG54542 AK127943 BAG54601 AK293213 BAH11469 AL831992 CAD89916 AM392959 CAL37837 BC023255 BC048309 BC065264 AAH65264 BC109038 AAI09039 BC109039 AAI09040 BC111047 AAI11048 DC409866 XM_005273833 XP_005273890 XM_005273834 XP_005273891 XM_005273835 XP_005273892 XM_011544811 XP_011543113 NM_152716 NP_689929
Function RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:19628699, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.
Subcellular Location Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:17936923}.
Top Pathways RNA degradation

PATL1-Over-expression-Lysate - LY16809a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PATL1 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PATL1 gene‘

PATL1 overexpression lysate - LY407336 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

PATL1 Overexpression Lysate (Native) - NBP2-05320 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PATL1 Overexpression Lysate (Adult Normal) [NBP2-05320] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PATL1.

Panoply™ Human PATL1 Knockdown Stable Cell Line - CSC-DC011336 from Creative biogene

Category Cell Line
Species Human

Human PATL1 Knockout Cell Line-HeLa - CSC-RT0930 from Creative biogene

Category Cell Line
Species Human

PATL1 KO Cell Lysate-HeLa - CLKO-0421 from Creative biogene

Category Cell Lysate
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