| Gene Symbol |
TYW5
|
| Entrez Gene |
129450
|
| Alt Symbol |
C2orf60, hTYW5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tRNA-yW synthesizing protein 5
|
| Other Description |
jmjC domain-containing protein C2orf60|tRNA wybutosine-synthesizing protein 5|tRNA yW-synthesizing enzyme 5|tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase
|
| Swissprots |
Q8N1R2 B2RNE3 A2RUC4
|
| Accessions |
A2RUC4 AAY24162 EAW70191 EAW70192 EAW70193 EAW70194 AK095272 BAC04517 AK293064 BAF85753 AK298977 BAG61071 BC025758 BC063502 AAH63502 BC132835 AAI32836 BC136837 AAI36838 BC144420 BM673915 BX482572 BX647677 BX648265 CB131724 CN261486 HQ258367 ADR83121 HY182974 XM_011510579 XP_011508881 NM_152382 NM_001039693 NP_001034782 NR_004862 NR_109905 NR_109906 NR_109907
|
| Function |
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. {ECO:0000269|PubMed:20739293}.
|
![Western Blot: TYW5 Overexpression Lysate (Adult Normal) [NBP2-08544] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TYW5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5832_TYW5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08544-img0001.jpg)