Gene Symbol | TYW5 |
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Entrez Gene | 129450 |
Alt Symbol | C2orf60, hTYW5 |
Species | Human |
Gene Type | protein-coding |
Description | tRNA-yW synthesizing protein 5 |
Other Description | jmjC domain-containing protein C2orf60|tRNA wybutosine-synthesizing protein 5|tRNA yW-synthesizing enzyme 5|tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase |
Swissprots | Q8N1R2 B2RNE3 A2RUC4 |
Accessions | A2RUC4 AAY24162 EAW70191 EAW70192 EAW70193 EAW70194 AK095272 BAC04517 AK293064 BAF85753 AK298977 BAG61071 BC025758 BC063502 AAH63502 BC132835 AAI32836 BC136837 AAI36838 BC144420 BM673915 BX482572 BX647677 BX648265 CB131724 CN261486 HQ258367 ADR83121 HY182974 XM_011510579 XP_011508881 NM_152382 NM_001039693 NP_001034782 NR_004862 NR_109905 NR_109906 NR_109907 |
Function | tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes. {ECO:0000269|PubMed:20739293}. |
C2orf60 CRISPR/Cas9 KO Plasmid (h) - sc-414350 from Santa Cruz Biotechnology
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C2orf60 HDR Plasmid (h) - sc-414350-HDR from Santa Cruz Biotechnology
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C2orf60 Double Nickase Plasmid (h) - sc-414350-NIC from Santa Cruz Biotechnology
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C2orf60 Double Nickase Plasmid (h2) - sc-414350-NIC-2 from Santa Cruz Biotechnology
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C2orf60 CRISPR Activation Plasmid (h) - sc-414350-ACT from Santa Cruz Biotechnology
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C2orf60 CRISPR Activation Plasmid (h2) - sc-414350-ACT-2 from Santa Cruz Biotechnology
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C2orf60 Lentiviral Activation Particles (h) - sc-414350-LAC from Santa Cruz Biotechnology
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C2orf60 Lentiviral Activation Particles (h2) - sc-414350-LAC-2 from Santa Cruz Biotechnology
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C2orf60 siRNA (h) - sc-94863 from Santa Cruz Biotechnology
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C2orf60 shRNA Plasmid (h) - sc-94863-SH from Santa Cruz Biotechnology
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C2orf60 shRNA (h) Lentiviral Particles - sc-94863-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU068571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4842 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4842 from Sigma-Aldrich
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TYW5 siRNA (Human) - CRJ5000 from Cohesion Biosciences
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TYW5 - MBS8225661 from MyBioSource
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shRNA set against Human TYW5 (NM_001039693.2) - SHH438544 from Creative biogene
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Human TYW5 siRNA - orb275501 from Biorbyt
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TYW5 shRNA Plasmid (Human) - CHJ5000 from Cohesion Biosciences
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TYW5 miRNA 3'UTR clone - MiUTR1H-03742 from Creative biogene
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