AXL

Gene Symbol	AXL
Entrez Gene	558
Alt Symbol	ARK, JTK11, Tyro7, UFO
Species	Human
Gene Type	protein-coding
Description	AXL receptor tyrosine kinase
Other Description	AXL oncogene|AXL transforming sequence/gene|tyrosine-protein kinase receptor UFO
Swissprots	P30530 Q9UD27 Q8N5L2
Accessions	CAA46829 CBX54237 CBX54238 EAW57022 EAW57023 P30530 AA021223 AI300772 AI309979 AK309139 AK310881 AL556721 BC032229 AAH32229 CA437238 DA478638 DQ894117 ABM85043 HY045208 M76125 AAA61243 S65125 AAB20305 X57019 CAA40338 X66029 NM_001278599 NP_001265528 NM_001699 NP_001690 NM_021913 NP_068713
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron sur
Subcellular Location	Cell membrane {ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.
Tissue Specificity	Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. {ECO:0000269|PubMed:7896447}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Total Axl Sandwich ELISA Kit - 7040 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-Axl (panTyr) Sandwich ELISA Kit - 7042 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

Axl Human ELISA Kit - ab99976 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 2 pg/ml Range 2.74 pg/ml - 2000 pg/ml

Human AXL ELISA Kit (Sandwich ELISA) - LS-F2608 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 2.743-666.7 pg/ml

Mouse AXL ELISA Kit (Sandwich ELISA) - LS-F2609 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 2.743-666.7 pg/ml

Human AXL ELISA Kit (Sandwich ELISA) - LS-F33 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.743 pg/ml Range 2.743-666.7 pg/ml

Mouse AXL ELISA Kit (Sandwich ELISA) - LS-F219 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 1.024 pg/ml Range 2.743-666.7 pg/ml

Rat AXL ELISA Kit (Sandwich ELISA) - LS-F9791 from LifeSpan Bioscience Category ELISA Kit Prices $860.00 Sizes 1 plate Sensitivity 0.9 ng/ml Range 2.743-666.7 pg/ml

Phosphotyrosine AXL / Tyrosine-protein Kinase Receptor UFO ELISA Kit - RAB0935 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Axl ELISA Kit - RAB0021 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human Phospho-Axl DuoSet IC Economy Pack, 15 Plate - DYC2228E from R&D Systems Category ELISA Kit

Human Phospho-Axl DuoSet IC ELISA - DYC2228-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)

Human Phospho-Axl DuoSet IC, 5 Plate - DYC2228-5 from R&D Systems Category ELISA Kit

Human Axl DuoSet ELISA - DY154 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Mouse Axl DuoSet ELISA - DY854 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Human Total Axl DuoSet IC Economy Pack, 15 Plate - DYC1643E from R&D Systems Category ELISA Kit

Human Total Axl DuoSet IC ELISA - DYC1643-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human Total Axl DuoSet IC, 5 Plate - DYC1643-5 from R&D Systems Category ELISA Kit

UFO ELISA Pair Set - orb145886 from Biorbyt Category ELISA Kit Prices $646.00, $1,369.00 Sizes 5 plates, 15 plates

Human AXL ELISA Kit - orb219227 from Biorbyt Category ELISA Kit Prices $706.00 Sizes 96 test Sensitivity 10 pg/ml Range 62.5 pg/ml-4000 pg/ml

Human AXL ELISA Kit - abx056013 from Abbexa Category ELISA Kit

Tyrosine-protein kinase receptor UFO, AXL, Human, ELISA Kit - E2483h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t

Tyrosine-Protein Kinase Receptor Ufo, AXL/UFO, Human, ELISA Kit - YHB3134Hu from ARP American Research Products Category ELISA Kit

AXL (Human) IP-WB Antibody Pair - H00000558-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

AXL (Human) Matched Antibody Pair - H00000558-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

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