AXL

Gene Symbol	AXL
Entrez Gene	558
Alt Symbol	ARK, JTK11, Tyro7, UFO
Species	Human
Gene Type	protein-coding
Description	AXL receptor tyrosine kinase
Other Description	AXL oncogene|AXL transforming sequence/gene|tyrosine-protein kinase receptor UFO
Swissprots	P30530 Q9UD27 Q8N5L2
Accessions	CAA46829 CBX54237 CBX54238 EAW57022 EAW57023 P30530 AA021223 AI300772 AI309979 AK309139 AK310881 AL556721 BC032229 AAH32229 CA437238 DA478638 DQ894117 ABM85043 HY045208 M76125 AAA61243 S65125 AAB20305 X57019 CAA40338 X66029 NM_001278599 NP_001265528 NM_001699 NP_001690 NM_021913 NP_068713
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron sur
Subcellular Location	Cell membrane {ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.
Tissue Specificity	Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. {ECO:0000269|PubMed:7896447}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Axl protein fragment - ab167950 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human Axl protein fragment - ab64298 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Axl protein fragment - ab42605 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Axl full length protein - ab152219 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Axl peptide - ab88168 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Axl protein fragment - ab152220 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Axl protein fragment - ab152221 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Axl protein fragment - ab191965 from Abcam Category Protein Prices $515.00 Sizes 200 µg Source HEK 293 cells Species Human

AXL Antibody Blocking Peptide - LS-E3843 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AXL Antibody Blocking Peptide - LS-E21591 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AXL Antibody Blocking Peptide - LS-E9092 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AXL Antibody Blocking Peptide - LS-E9091 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Axl Protein - H00000558-Q03 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Axl Protein - H00000558-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Axl Protein - H00000558-P01 from Novus Biologicals Category Protein Prices $299.00 Sizes 2 µg Source Wheat Germ Species Human

Axl Recombinant Protein - P4654 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Axl Peptide - P2613 from Novus Biologicals Category Peptide Species Human

Axl Peptide - P2612 from Novus Biologicals Category Peptide Species Human

AXL-Antibody-C-term-Blocking-Peptide - BP7602b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AXL-Antibody-N-term-Blocking-Peptide - BP7602a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Axl Fc Chimera, CF - 154-AL-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Mouse UFO protein - orb83228 from Biorbyt Category Protein Prices $570.00, $748.00 Sizes 50 μg, 100 μg Source Mouse Species Human

Human UFO protein - orb83848 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

AXL Blocking Peptide - 33R-7673 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

AXL (phospho-Tyr697) Blocking Peptide - abx064128 from Abbexa Category Peptide Species Human, Mouse, Rat

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