AXL

Gene Symbol	AXL
Entrez Gene	558
Alt Symbol	ARK, JTK11, Tyro7, UFO
Species	Human
Gene Type	protein-coding
Description	AXL receptor tyrosine kinase
Other Description	AXL oncogene|AXL transforming sequence/gene|tyrosine-protein kinase receptor UFO
Swissprots	P30530 Q9UD27 Q8N5L2
Accessions	CAA46829 CBX54237 CBX54238 EAW57022 EAW57023 P30530 AA021223 AI300772 AI309979 AK309139 AK310881 AL556721 BC032229 AAH32229 CA437238 DA478638 DQ894117 ABM85043 HY045208 M76125 AAA61243 S65125 AAB20305 X57019 CAA40338 X66029 NM_001278599 NP_001265528 NM_001699 NP_001690 NM_021913 NP_068713
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron sur
Subcellular Location	Cell membrane {ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.
Tissue Specificity	Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. {ECO:0000269|PubMed:7896447}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Axl siRNA I - 6263 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Axl siRNA II - 6264 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Axl CRISPR/Cas9 KO Plasmid (h) - sc-400393 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Axl HDR Plasmid (h) - sc-400393-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Axl Double Nickase Plasmid (h) - sc-400393-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Axl Double Nickase Plasmid (h2) - sc-400393-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Axl CRISPR Activation Plasmid (h) - sc-400393-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Axl CRISPR Activation Plasmid (h2) - sc-400393-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Axl Lentiviral Activation Particles (h) - sc-400393-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Axl Lentiviral Activation Particles (h2) - sc-400393-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Axl siRNA (h) - sc-29769 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Axl shRNA Plasmid (h) - sc-29769-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Axl shRNA (h) Lentiviral Particles - sc-29769-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Axl siRNA (h2) - sc-44285 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Axl shRNA Plasmid (h2) - sc-44285-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Axl shRNA (h2) Lentiviral Particles - sc-44285-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Axl RNAi - H00000558-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Axl RNAi - H00000558-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU081461 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0151 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0149 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0150 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2013 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2013 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

AXL siRNA (Human) - CRH0384 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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