AXL

Gene Symbol	AXL
Entrez Gene	558
Alt Symbol	ARK, JTK11, Tyro7, UFO
Species	Human
Gene Type	protein-coding
Description	AXL receptor tyrosine kinase
Other Description	AXL oncogene|AXL transforming sequence/gene|tyrosine-protein kinase receptor UFO
Swissprots	P30530 Q9UD27 Q8N5L2
Accessions	CAA46829 CBX54237 CBX54238 EAW57022 EAW57023 P30530 AA021223 AI300772 AI309979 AK309139 AK310881 AL556721 BC032229 AAH32229 CA437238 DA478638 DQ894117 ABM85043 HY045208 M76125 AAA61243 S65125 AAB20305 X57019 CAA40338 X66029 NM_001278599 NP_001265528 NM_001699 NP_001690 NM_021913 NP_068713
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron sur
Subcellular Location	Cell membrane {ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.
Tissue Specificity	Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. {ECO:0000269|PubMed:7896447}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-AXL-cDNA-Clone - DC15225 from Abgent, a WuXi AppTec company Prices $1,208.25 Sizes 10 µg Species Human Accession BC032229

Human Axl (AAH32229) VersaClone cDNA - RDC0598 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

Mouse Axl (NP_033491) VersaClone cDNA - RDC1194 from R&D Systems Prices $499.00 Sizes 10 µg Species Mouse

AXL - MBS1269583 from MyBioSource Species Human Accession BC032229

Human AXL transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10279-M from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10279-ACR from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10279-ACG from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10279-NH from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10279-UT from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10279-CY from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10279-NF from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10279-CF from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10279-NM from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10279-CH from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10279-NY from Sino Biological Species Human

Human AXL transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10279-CM from Sino Biological Species Human

Human AXL ORF Clone(NM_001699.4) - CDCR281311 from Creative biogene Species Human

Human AXL ORF clone (NM_021913.3) - CDCR032594 from Creative biogene Species Human

Human AXL ORF Clone (BC032229) - CDCS410387 from Creative biogene Species Human Accession P30530

Human AXL/UFO Gene - orb90869 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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