LCP2

Gene Symbol LCP2
Entrez Gene 3937
Alt Symbol SLP-76, SLP76
Species Human
Gene Type protein-coding
Description lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Other Description 76 kDa tyrosine phosphoprotein|SH2 domain-containing leukocyte protein of 76 kDa|SH2 domain-containing leukocyte protein of 76kD|SLP-76 tyrosine phosphoprotein|lymphocyte cytosolic protein 2
Swissprots Q53XV4 A8KA25 Q13094
Accessions AAA93308 EAW61478 EAW61479 EAW61480 Q13094 AK122637 AK292890 BAF85579 AK296098 BAG58851 AK300000 BAG61819 AK310369 BC016618 AAH16618 BG911397 BT007273 AAP35937 DQ890681 ABM81607 DQ893863 ABM84789 FN432830 CBA11531 U20158 AAC50135 XM_011534558 XP_011532860 NM_005565 NP_005556
Function Involved in T-cell antigen receptor mediated signaling.
Subcellular Location Cytoplasm {ECO:0000305}.
Tissue Specificity Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.
Top Pathways Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Osteoclast differentiation, Rap1 signaling pathway

Phospho-SLP-76 (Ser376) Antibody - 13177 from Cell Signaling Technology

Prices $279.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from EL4 cells, untreated (-) or treated with H2O2 (11 mM, 1 min; +), using Phospho-SLP-76 (Ser376) Antibody (upper) or SLP-76 Antibody #4958 (lower).

Phospho-SLP-76 (Tyr145) Antibody - 14770 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells, untreated (-) or H 2 O 2 -treated (11 mM, 1 min; +), using Phospho-SLP-76 (Tyr145) Antibody (upper) and SLP-76 Antibody #4958 (lower).

SLP-76 Antibody - 4958 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat and BW5147cells using SLP-76 Antibody.

SLP-76 (C-20) - sc-1961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SLP-76 (C-20): sc-1961. Western blot analysis of SLP-76 expression in non-transfected: sc-117752 (A) and mouse SLP-76 transfected: sc-126013 (B) 293T whole cell lysates.

SLP-76 (F-7) - sc-13151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SLP-76 (F-7): sc-13151. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing cytoplasmic and membrane staining of follicle and non-follicle cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

SLP-76 (H-300) - sc-9062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SLP-76 (H-300): sc-9062. Immunofluor?escence staining of normal mouse heart frozen section showing cytoplasmic staining.

SLP-76 (SLP-76/03) - sc-51698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SLP-76 (SLP-76/03): sc-51698. Western blot analysis of SLP-76 expression in AML-193 (A), THP-1 (B) and BJAB (C) whole cell lysates.

SLP-76 (8) - sc-136070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
SLP-76 (8): sc-136070. Western blot analysis of SLP-76 expression in Jurkat whole cell lysate.

Anti-SLP76 (phospho Y113) antibody [EPR2851] - ab75990 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2851
All lanes : Anti-SLP76 (phospho Y113) antibody [EPR2851] (ab75990) at 1/10000 dilutionLane 1 : Jurkat cell lysate - untreatedLane 2 : Jurkat cell lysate - treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SLP76 (phospho Y145) antibody [EP2853Y] - ab75829 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2853Y
All lanes : Anti-SLP76 (phospho Y145) antibody [EP2853Y] (ab75829) at 1/200000 dilutionLane 1 : Jurkat cell lysates un-treatedLane 2 : Jurkat cell lysates treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SLP76 antibody - ab196599 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SLP76 antibody (ab196599) at 1/500 dilutionLane 1 : U937 cell extractLane 2 : BT-474 cell extractLane 3 : Mouse spleen extractLane 4 : Mouse liver extract

Anti-SLP76 antibody - ab187522 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse spleen tissue labelling SLP76 with ab187522 at 1/100. Magnification: 400x.

Anti-SLP76 antibody - ab14942 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLP76 antibody - ab137190 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SLP76 antibody (ab137190) at 1/500 dilution + HT29 cell lysate at 30 µg

Anti-SLP76 antibody - ab17029 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SLP76 antibody [EPR2549(2)] - ab109254 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2549(2)
All lanes : Anti-SLP76 antibody [EPR2549(2)] (ab109254) at 1/1000 dilutionLane 1 : MOLT4 cell lysateLane 2 : HuT78 cell lysateLysates/proteins at 10 µg per lane.

Anti-SLP76 antibody [SLP-76/03] - ab14940 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone SLP-76/03

Anti-LCP2 / SLP-76 Antibody (aa216-434, clone SLP-76/03) - LS-C204152 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone SLP-76/03

Anti-LCP2 / SLP-76 Antibody (aa216-434) - LS-C204202 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LCP2 / SLP-76 Antibody (phospho-Tyr145, clone EP2853Y) - LS-C105379 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2853Y
Western blot analysis on Jurkat cell lysates using anti-Phospho-SLP-76 (pY145) antibody (LS-C105379), 1:200000 dilution. Cells were either (A) untreated (B) treated with pervanadate.

Anti-LCP2 / SLP-76 Antibody (phospho-Tyr113, clone EPR2851) - LS-C105348 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2851
Western blot analysis on Jurkat cell lysates using anti-Phospho-SLP-76 (pY113) antibody (LS-C105348), 1:10000 dilution. Cells were either (A) untreated (B) treated with pervanadate.

Anti-LCP2 / SLP-76 Antibody (phospho-Tyr128) - LS-C291634 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LCP2 / SLP-76 Antibody (aa94-143) - LS-C118332 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using SLP-76 (Ab-128) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-LCP2 / SLP-76 Antibody (phospho-Tyr128) - LS-C313634 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LCP2 / SLP-76 Antibody (aa339-384) - LS-C313959 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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