Gene Symbol | LCP2 |
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Entrez Gene | 3937 |
Alt Symbol | SLP-76, SLP76 |
Species | Human |
Gene Type | protein-coding |
Description | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) |
Other Description | 76 kDa tyrosine phosphoprotein|SH2 domain-containing leukocyte protein of 76 kDa|SH2 domain-containing leukocyte protein of 76kD|SLP-76 tyrosine phosphoprotein|lymphocyte cytosolic protein 2 |
Swissprots | Q53XV4 A8KA25 Q13094 |
Accessions | AAA93308 EAW61478 EAW61479 EAW61480 Q13094 AK122637 AK292890 BAF85579 AK296098 BAG58851 AK300000 BAG61819 AK310369 BC016618 AAH16618 BG911397 BT007273 AAP35937 DQ890681 ABM81607 DQ893863 ABM84789 FN432830 CBA11531 U20158 AAC50135 XM_011534558 XP_011532860 NM_005565 NP_005556 |
Function | Involved in T-cell antigen receptor mediated signaling. |
Subcellular Location | Cytoplasm {ECO:0000305}. |
Tissue Specificity | Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. |
Top Pathways | Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Osteoclast differentiation, Rap1 signaling pathway |
SLP-76 CRISPR/Cas9 KO Plasmid (h) - sc-401421 from Santa Cruz Biotechnology
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SLP-76 HDR Plasmid (h) - sc-401421-HDR from Santa Cruz Biotechnology
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SLP-76 Double Nickase Plasmid (h) - sc-401421-NIC from Santa Cruz Biotechnology
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SLP-76 Double Nickase Plasmid (h2) - sc-401421-NIC-2 from Santa Cruz Biotechnology
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SLP-76 CRISPR Activation Plasmid (h) - sc-401421-ACT from Santa Cruz Biotechnology
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SLP-76 CRISPR Activation Plasmid (h2) - sc-401421-ACT-2 from Santa Cruz Biotechnology
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SLP-76 Lentiviral Activation Particles (h) - sc-401421-LAC from Santa Cruz Biotechnology
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SLP-76 Lentiviral Activation Particles (h2) - sc-401421-LAC-2 from Santa Cruz Biotechnology
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SLP-76 siRNA (h) - sc-36501 from Santa Cruz Biotechnology
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SLP-76 shRNA Plasmid (h) - sc-36501-SH from Santa Cruz Biotechnology
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SLP-76 shRNA (h) Lentiviral Particles - sc-36501-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU150991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11613 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11613 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06026 from Sigma-Aldrich
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LCP2 siRNA (Human) - CRH2668 from Cohesion Biosciences
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shRNA set against Human LCP2 (NM_005565.3) - SHH329199 from Creative biogene
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shRNA set against Human LCP2(NM_005565.3) - SHH144893 from Creative biogene
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Human LCP2 siRNA - orb263170 from Biorbyt
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LCP2 shRNA Plasmid (Human) - CHH2668 from Cohesion Biosciences
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LCP2 miRNA 3'UTR clone - MiUTR1H-05616 from Creative biogene
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