| Gene Symbol |
LCP2
|
| Entrez Gene |
3937
|
| Alt Symbol |
SLP-76, SLP76
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
|
| Other Description |
76 kDa tyrosine phosphoprotein|SH2 domain-containing leukocyte protein of 76 kDa|SH2 domain-containing leukocyte protein of 76kD|SLP-76 tyrosine phosphoprotein|lymphocyte cytosolic protein 2
|
| Swissprots |
Q53XV4 A8KA25 Q13094
|
| Accessions |
AAA93308 EAW61478 EAW61479 EAW61480 Q13094 AK122637 AK292890 BAF85579 AK296098 BAG58851 AK300000 BAG61819 AK310369 BC016618 AAH16618 BG911397 BT007273 AAP35937 DQ890681 ABM81607 DQ893863 ABM84789 FN432830 CBA11531 U20158 AAC50135 XM_011534558 XP_011532860 NM_005565 NP_005556
|
| Function |
Involved in T-cell antigen receptor mediated signaling.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Osteoclast differentiation, Rap1 signaling pathway
|
![Western Blot: SLP76 Overexpression Lysate (Adult Normal) [NBL1-12467] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLP76.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12149_SLP76%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-12467-img0002.jpg)