| Gene Symbol | LCP2 |
|---|---|
| Entrez Gene | 3937 |
| Alt Symbol | SLP-76, SLP76 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) |
| Other Description | 76 kDa tyrosine phosphoprotein|SH2 domain-containing leukocyte protein of 76 kDa|SH2 domain-containing leukocyte protein of 76kD|SLP-76 tyrosine phosphoprotein|lymphocyte cytosolic protein 2 |
| Swissprots | Q53XV4 A8KA25 Q13094 |
| Accessions | AAA93308 EAW61478 EAW61479 EAW61480 Q13094 AK122637 AK292890 BAF85579 AK296098 BAG58851 AK300000 BAG61819 AK310369 BC016618 AAH16618 BG911397 BT007273 AAP35937 DQ890681 ABM81607 DQ893863 ABM84789 FN432830 CBA11531 U20158 AAC50135 XM_011534558 XP_011532860 NM_005565 NP_005556 |
| Function | Involved in T-cell antigen receptor mediated signaling. |
| Subcellular Location | Cytoplasm {ECO:0000305}. |
| Tissue Specificity | Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. |
| Top Pathways | Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Osteoclast differentiation, Rap1 signaling pathway |