| Gene Symbol |
SDHAF2
|
| Entrez Gene |
54949
|
| Alt Symbol |
C11orf79, PGL2, SDH5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
succinate dehydrogenase complex assembly factor 2
|
| Other Description |
SDH assembly factor 2|hSDH5|succinate dehydrogenase assembly factor 2, mitochondrial|succinate dehydrogenase subunit 5, mitochondrial
|
| Swissprots |
Q9NX18
|
| Accessions |
EAW73951 Q9NX18 AI039966 AI660205 AK000494 BAA91204 BC002331 AAH02331 BX648946 NM_017841 NP_060311
|
| Function |
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03057, ECO:0000269|PubMed:19628817}.
|
![Western Blot: PGL2 Overexpression Lysate (Adult Normal) [NBL1-08123] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PGL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3912_PGL2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08123-img0002.jpg)