Gene Symbol | SDHAF2 |
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Entrez Gene | 54949 |
Alt Symbol | C11orf79, PGL2, SDH5 |
Species | Human |
Gene Type | protein-coding |
Description | succinate dehydrogenase complex assembly factor 2 |
Other Description | SDH assembly factor 2|hSDH5|succinate dehydrogenase assembly factor 2, mitochondrial|succinate dehydrogenase subunit 5, mitochondrial |
Swissprots | Q9NX18 |
Accessions | EAW73951 Q9NX18 AI039966 AI660205 AK000494 BAA91204 BC002331 AAH02331 BX648946 NM_017841 NP_060311 |
Function | Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}. |
Subcellular Location | Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03057, ECO:0000269|PubMed:19628817}. |
SDHAF2 CRISPR/Cas9 KO Plasmid (h) - sc-418089 from Santa Cruz Biotechnology
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SDHAF2 HDR Plasmid (h) - sc-418089-HDR from Santa Cruz Biotechnology
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SDHAF2 Double Nickase Plasmid (h) - sc-418089-NIC from Santa Cruz Biotechnology
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SDHAF2 Double Nickase Plasmid (h2) - sc-418089-NIC-2 from Santa Cruz Biotechnology
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SDHAF2 CRISPR Activation Plasmid (h) - sc-418089-ACT from Santa Cruz Biotechnology
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SDHAF2 CRISPR Activation Plasmid (h2) - sc-418089-ACT-2 from Santa Cruz Biotechnology
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SDHAF2 Lentiviral Activation Particles (h) - sc-418089-LAC from Santa Cruz Biotechnology
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SDHAF2 Lentiviral Activation Particles (h2) - sc-418089-LAC-2 from Santa Cruz Biotechnology
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SDHAF2 siRNA (h) - sc-96879 from Santa Cruz Biotechnology
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SDHAF2 shRNA Plasmid (h) - sc-96879-SH from Santa Cruz Biotechnology
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SDHAF2 shRNA (h) Lentiviral Particles - sc-96879-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU048221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18999 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18999 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06720 from Sigma-Aldrich
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SDHAF2 siRNA (Human) - CRJ0350 from Cohesion Biosciences
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SDHAF2 - MBS8219290 from MyBioSource
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shRNA set against Human SDHAF2 (NM_017841.2) - SHH403400 from Creative biogene
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Human SDHAF2 siRNA - orb270851 from Biorbyt
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SDHAF2 shRNA Plasmid (Human) - CHJ0350 from Cohesion Biosciences
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SDHAF2 miRNA 3'UTR clone - MiUTR3H-12728 from Creative biogene
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