ROCK1

Gene Symbol ROCK1
Entrez Gene 6093
Alt Symbol P160ROCK, ROCK-I
Species Human
Gene Type protein-coding
Description Rho-associated, coiled-coil containing protein kinase 1
Other Description Rho kinase|p160 ROCK-1|p160-ROCK|renal carcinoma antigen NY-REN-35|rho-associated protein kinase 1|rho-associated, coiled-coil-containing protein kinase 1|rho-associated, coiled-coil-containing protein kinase I
Swissprots B0YJ91 Q13464 Q59GZ4 Q2KHM4
Accessions ACA06069 ADL14517 EAX01119 Q13464 AB208965 BAD92202 AK057038 AK307388 AU121527 BC113114 AAI13115 DQ786321 U43195 AAB02814 XM_011526136 XP_011524438 XM_011526137 XP_011524439 NM_005406 NP_005397
Function Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte termina
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi membranes. {ECO:0000250}.
Tissue Specificity Detected in blood platelets. {ECO:0000269|PubMed:8617235}.
Top Pathways Chemokine signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Proteoglycans in cancer

Rho-associated, coiled-coil containing protein kinase 1, ELISA Kit - MBS9318720 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml.
Range 0.25ng/ml-8ng/ml.

Human ROCK1 ELISA Kit - E096286 from Biobool

Category ELISA Kit

anti-ROCK1 antibody - ARG56252 from Arigo Biolaboratories

Category ELISA Kit

ROCK1 ELISA Kit (Human) (OKEH06554) - OKEH06554 from Aviva Systems Biology

Category ELISA Kit
Prices $480.00
Sizes 96 wells
Sensitivity 0.625 ng/mL
Range 0.625-40 ng/mL

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9355042 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9367081 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9344463 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9361356 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9364420 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9351606 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9343708 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9363763 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9368118 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9348119 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9348942 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9357383 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9344588 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9357812 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9355933 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9348320 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9379759 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9365119 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9362481 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rho-Associated Protein Kinase 1 (ROCK1), ELISA Kit - MBS9349978 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat Rho Kinase / ROCK1 ELISA Kit (Sandwich ELISA) - LS-F32208 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 31.25
Range 125-8000 pg/ml
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