ROCK1

Gene Symbol	ROCK1
Entrez Gene	6093
Alt Symbol	P160ROCK, ROCK-I
Species	Human
Gene Type	protein-coding
Description	Rho-associated, coiled-coil containing protein kinase 1
Other Description	Rho kinase|p160 ROCK-1|p160-ROCK|renal carcinoma antigen NY-REN-35|rho-associated protein kinase 1|rho-associated, coiled-coil-containing protein kinase 1|rho-associated, coiled-coil-containing protein kinase I
Swissprots	B0YJ91 Q13464 Q59GZ4 Q2KHM4
Accessions	ACA06069 ADL14517 EAX01119 Q13464 AB208965 BAD92202 AK057038 AK307388 AU121527 BC113114 AAI13115 DQ786321 U43195 AAB02814 XM_011526136 XP_011524438 XM_011526137 XP_011524439 NM_005406 NP_005397
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte termina
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi membranes. {ECO:0000250}.
Tissue Specificity	Detected in blood platelets. {ECO:0000269|PubMed:8617235}.
Top Pathways	Chemokine signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ROCK1 (C8F7) Rabbit mAb - 4035 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C8F7

Rock-1 (B-1) - sc-374388 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rock-1 (C-19) - sc-6055 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rock-1 (H-11) - sc-365628 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rock-1 (G-6) - sc-17794 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rock-1 (H-85) - sc-5560 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Rock-1 (K-18) - sc-6056 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rock-1 (D-18) - sc-87350 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Rock-1 (C-12) - sc-87349 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

cleaved Rock-1 (h1113) - sc-34326 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

cleaved Rock-1 (4H247) - sc-71965 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

cleaved Rock-1 (154C1465) - sc-52953 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-ROCK1 (phospho T455 + S456) antibody - ab203273 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROCK1 antibody - ab58305 from Abcam Prices $385.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ROCK1 antibody - ab97592 from Abcam Prices $384.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-ROCK1 antibody - ab105107 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ROCK1 antibody - ab50314 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROCK1 antibody - ab133794 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ROCK1 antibody [EP786Y] - ab45171 from Abcam Prices $401.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP786Y

Anti-ROCK1 antibody [EPR638Y] - ab134181 from Abcam Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR638Y

Anti-ROCK1 antibody [GT261] - ab184617 from Abcam Prices $376.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone GT261

Anti-ROCK1 antibody - C-terminal - ab199899 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROCK1 antibody - N-terminal - ab156284 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ROCK1 Cleavage Site (1113/1114) antibody [154C1465] - ab13660 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 154C1465

Anti-Rho Kinase / ROCK1 Antibody - LS-C48506 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Mouse Clonality Monoclonal

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