| Gene Symbol |
ROCK1
|
| Entrez Gene |
6093
|
| Alt Symbol |
P160ROCK, ROCK-I
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho-associated, coiled-coil containing protein kinase 1
|
| Other Description |
Rho kinase|p160 ROCK-1|p160-ROCK|renal carcinoma antigen NY-REN-35|rho-associated protein kinase 1|rho-associated, coiled-coil-containing protein kinase 1|rho-associated, coiled-coil-containing protein kinase I
|
| Swissprots |
B0YJ91 Q13464 Q59GZ4 Q2KHM4
|
| Accessions |
ACA06069 ADL14517 EAX01119 Q13464 AB208965 BAD92202 AK057038 AK307388 AU121527 BC113114 AAI13115 DQ786321 U43195 AAB02814 XM_011526136 XP_011524438 XM_011526137 XP_011524439 NM_005406 NP_005397
|
| Function |
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte termina
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi membranes. {ECO:0000250}.
|
| Tissue Specificity |
Detected in blood platelets. {ECO:0000269|PubMed:8617235}.
|
| Top Pathways |
Chemokine signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Proteoglycans in cancer
|