ROCK1

Gene Symbol	ROCK1
Entrez Gene	6093
Alt Symbol	P160ROCK, ROCK-I
Species	Human
Gene Type	protein-coding
Description	Rho-associated, coiled-coil containing protein kinase 1
Other Description	Rho kinase|p160 ROCK-1|p160-ROCK|renal carcinoma antigen NY-REN-35|rho-associated protein kinase 1|rho-associated, coiled-coil-containing protein kinase 1|rho-associated, coiled-coil-containing protein kinase I
Swissprots	B0YJ91 Q13464 Q59GZ4 Q2KHM4
Accessions	ACA06069 ADL14517 EAX01119 Q13464 AB208965 BAD92202 AK057038 AK307388 AU121527 BC113114 AAI13115 DQ786321 U43195 AAB02814 XM_011526136 XP_011524438 XM_011526137 XP_011524439 NM_005406 NP_005397
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte termina
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi membranes. {ECO:0000250}.
Tissue Specificity	Detected in blood platelets. {ECO:0000269|PubMed:8617235}.
Top Pathways	Chemokine signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ROCK1 protein fragment - ab51415 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human ROCK1 protein fragment - ab159365 from Abcam Category Protein Source Wheat germ Species Human

Rho Kinase / ROCK1 Antibody Blocking Peptide - LS-E31111 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human ROCK1 Protein - H00006093-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ROCK1 Recombinant Protein - P3913 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

ROCK1 Blocking Peptide - NBP1-76569PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human Active ROCK1, CF - 4590-KS-010 from R&D Systems Category Protein

ROCK1 peptide - orb73177 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

ROCK1 Blocking Peptide - abx063207 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey, Pig, Rabbit

ROCK1 - H00006093-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ROCK1 - H00006093-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ROCK1 - P3913 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

ROCK1 control peptide - AP26128CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ROCK1 Peptide - 6295P from ProSci Category Peptide Species Human

ROCK1 fusion protein - ag17393 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ROCK1 fusion protein - Ag16317 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ROCK1, GST-tagged - ROCK1-420H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human ROCK1 - ROCK1-30952TH from Creative Biomart Category Protein

Recombinant Human ROCK1 - ROCK1-552H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human ROCK1, GST-tagged - ROCK1-574H from Creative Biomart Category Protein Source Sf 9 insect cells Species Human

Recombinant Human ROCK1 (Active), GST-tagged - ROCK1-1480H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Rho Associated Coiled Coil Containing Protein Kinase 1 (Rock1) - RPE705Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

ROKα/ROCK-II Protein, active, rat, 10 µg - 14-338 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg Source Rat ROKa/ROCK-II expressed in Sf21 insect cells. Species Rat

ROKα/ROCK-II Protein, active, 250 µg - 14-451M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-451) and in bulk (cat# 14-451-K) Source expressed by baculovirus in Sf21 insect cells

ROKβ/ROCK-I Protein, active, 10 µg - 14-601 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source expressed by baculovirus in Sf21 insect cells

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