| Gene Symbol |
RRAGD
|
| Entrez Gene |
58528
|
| Alt Symbol |
RAGD, bA11D8.2.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras-related GTP binding D
|
| Other Description |
Rag D protein|ras-related GTP-binding protein D
|
| Swissprots |
A8K184 Q7L8F9 Q9NPG0 Q9NQL2
|
| Accessions |
EAW48554 Q9NQL2 AF272036 AAG32663 AJ420486 AK126164 AK289799 BAF82488 AL137502 CAB70775 AL523999 BC003088 AAH03088 DB472739 JF432487 ADZ15704 XM_005248755 XP_005248812 XM_011536022 XP_011534324 NM_021244 NP_067067
|
| Function |
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. {ECO:0000269|PubMed:20381137}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.
|
| Top Pathways |
mTOR signaling pathway
|