Gene Symbol | RRAGD |
---|---|
Entrez Gene | 58528 |
Alt Symbol | RAGD, bA11D8.2.1 |
Species | Human |
Gene Type | protein-coding |
Description | Ras-related GTP binding D |
Other Description | Rag D protein|ras-related GTP-binding protein D |
Swissprots | A8K184 Q7L8F9 Q9NPG0 Q9NQL2 |
Accessions | EAW48554 Q9NQL2 AF272036 AAG32663 AJ420486 AK126164 AK289799 BAF82488 AL137502 CAB70775 AL523999 BC003088 AAH03088 DB472739 JF432487 ADZ15704 XM_005248755 XP_005248812 XM_011536022 XP_011534324 NM_021244 NP_067067 |
Function | Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. {ECO:0000269|PubMed:20381137}. |
Subcellular Location | Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA. |
Top Pathways | mTOR signaling pathway |