Gene Symbol | CDK16 |
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Entrez Gene | 5127 |
Alt Symbol | PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1 |
Species | Human |
Gene Type | protein-coding |
Description | cyclin-dependent kinase 16 |
Other Description | PCTAIRE-motif protein kinase 1|cell division protein kinase 16|serine/threonine-protein kinase PCTAIRE-1 |
Swissprots | Q00536 A8K280 B7Z7C8 J3KQP7 J3KN74 |
Accessions | EAW59294 EAW59295 EAW59296 EAW59297 EAW59298 Q00536 AB209465 BAD92702 AK096881 AK131486 BAD18631 AK290145 BAF82834 AK296880 BAH12447 AK301832 BAH13564 AK303849 BAH14066 BC001048 AAH01048 BC006190 AAH06190 BC009852 AAH09852 BC015607 AAH15607 BG029956 BQ187876 BT006827 AAP35473 DA816614 DA900611 X66363 CAA47006 XM_011543920 XP_011542222 XM_011543921 XP_011542223 XM_011543922 XP_011542224 XM_011543923 XP_011542225 XM_011543924 XP_011542226 XM_011543925 XP_011542227 XM_011543926 XP_011542228 XM_011543927 XP_011542229 XM_011543928 XP_011542230 XR_949017 NM_001170460 NP_001163931 NM_006201 NP_006192 NM_033018 NP_148978 |
Function | Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser- 336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. |
Subcellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY. |
Tissue Specificity | Detected in pancreas islets (at protein level). Detected in brain and pancreas. {ECO:0000269|PubMed:22798068}. |
PCTAIRE 1 Antibody - 4852 from Cell Signaling Technology
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PCTAIRE-1 (C-16) - sc-174 from Santa Cruz Biotechnology
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PCTAIRE-1 (G-1) - sc-166242 from Santa Cruz Biotechnology
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PCTAIRE-1 (G6.1) - sc-53410 from Santa Cruz Biotechnology
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PCTAIRE-1 (H-70) - sc-22775 from Santa Cruz Biotechnology
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Anti-PCTAIRE1 antibody - ab37895 from Abcam
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Anti-PCTAIRE1 antibody - ab55552 from Abcam
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Anti-PCTAIRE1 antibody - ab55553 from Abcam
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Anti-PCTAIRE1 antibody [EPR13210] - ab181208 from Abcam
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Anti-PCTAIRE1 antibody [EPR13210-141] - ab185542 from Abcam
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Anti-PCTAIRE1 antibody [G6.1] - ab11043 from Abcam
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Anti-CDK16 / PCTAIRE Antibody - LS-C38107 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (C-Terminus, AP) - LS-C280634 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (C-Terminus, Biotin) - LS-C280636 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (C-Terminus, APC) - LS-C280635 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (C-Terminus, Azide-free, HRP) - LS-C280638 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (C-Terminus, FITC) - LS-C280637 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (C-Terminus, PE) - LS-C280639 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (aa446-496) - LS-C291009 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (C-Terminus) - LS-C328165 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (N-Terminus) - LS-C112292 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (clone 4D2) - LS-C133368 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (aa25-75) - LS-C291008 from LifeSpan Bioscience
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Anti-CDK16 / PCTAIRE Antibody (N-Terminus) - LS-C99041 from LifeSpan Bioscience
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PCTAIRE1 Antibody - NBP1-92248 from Novus Biologicals
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