| Gene Symbol | C3 |
|---|---|
| Entrez Gene | 718 |
| Alt Symbol | AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 3 |
| Other Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1|C3a anaphylatoxin|acylation-stimulating protein cleavage product|complement C3|complement component C3|complement component C3a|complement component C3b|epididymis secretory sperm binding protein Li 62p|prepro-C3 |
| Swissprots | A7E236 P01024 |
| Accessions | AAA35722 AAR89906 CAI46844 EAW69070 EAW69071 P01024 AA025232 AI758500 AK094728 AK304071 BAG64978 BC022897 BC063852 BC150179 AAI50180 BC150200 AAI50201 BC150299 BP201387 BP349355 EU794602 ACJ13656 K02765 AAA85332 KC493376 KC493377 M55658 NM_000064 NP_000055 |
| Function | C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. {ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:9555951}. |
| Top Pathways | Phagosome, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection, Complement and coagulation cascades, Pertussis |