Gene Symbol | C3 |
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Entrez Gene | 718 |
Alt Symbol | AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p |
Species | Human |
Gene Type | protein-coding |
Description | complement component 3 |
Other Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1|C3a anaphylatoxin|acylation-stimulating protein cleavage product|complement C3|complement component C3|complement component C3a|complement component C3b|epididymis secretory sperm binding protein Li 62p|prepro-C3 |
Swissprots | A7E236 P01024 |
Accessions | AAA35722 AAR89906 CAI46844 EAW69070 EAW69071 P01024 AA025232 AI758500 AK094728 AK304071 BAG64978 BC022897 BC063852 BC150179 AAI50180 BC150200 AAI50201 BC150299 BP201387 BP349355 EU794602 ACJ13656 K02765 AAA85332 KC493376 KC493377 M55658 NM_000064 NP_000055 |
Function | C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000250}. |
Subcellular Location | Secreted. |
Tissue Specificity | Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. {ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:9555951}. |
Top Pathways | Phagosome, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection, Complement and coagulation cascades, Pertussis |
C3 CRISPR/Cas9 KO Plasmid (h) - sc-400622 from Santa Cruz Biotechnology
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C3 HDR Plasmid (h) - sc-400622-HDR from Santa Cruz Biotechnology
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C3 Double Nickase Plasmid (h) - sc-400622-NIC from Santa Cruz Biotechnology
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C3 Double Nickase Plasmid (h2) - sc-400622-NIC-2 from Santa Cruz Biotechnology
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C3 CRISPR Activation Plasmid (h) - sc-400622-ACT from Santa Cruz Biotechnology
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C3 CRISPR Activation Plasmid (h2) - sc-400622-ACT-2 from Santa Cruz Biotechnology
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C3 Lentiviral Activation Particles (h) - sc-400622-LAC from Santa Cruz Biotechnology
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C3 Lentiviral Activation Particles (h2) - sc-400622-LAC-2 from Santa Cruz Biotechnology
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C3 siRNA (h) - sc-37068 from Santa Cruz Biotechnology
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C3 shRNA Plasmid (h) - sc-37068-SH from Santa Cruz Biotechnology
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C3 shRNA (h) Lentiviral Particles - sc-37068-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU041341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4871 from Sigma-Aldrich
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C3 siRNA (Human) - CRH0497 from Cohesion Biosciences
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Complement C3 RNAi - H00000718-R01 from Novus Biologicals
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C3 - MBS8232275 from MyBioSource
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Human C3 siRNA - orb260999 from Biorbyt
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C3 shRNA Plasmid (Human) - CHH0497 from Cohesion Biosciences
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C3 miRNA 3'UTR clone - MiUTR1H-01373 from Creative biogene
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