| Gene Symbol |
C3
|
| Entrez Gene |
718
|
| Alt Symbol |
AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
complement component 3
|
| Other Description |
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1|C3a anaphylatoxin|acylation-stimulating protein cleavage product|complement C3|complement component C3|complement component C3a|complement component C3b|epididymis secretory sperm binding protein Li 62p|prepro-C3
|
| Swissprots |
A7E236 P01024
|
| Accessions |
AAA35722 AAR89906 CAI46844 EAW69070 EAW69071 P01024 AA025232 AI758500 AK094728 AK304071 BAG64978 BC022897 BC063852 BC150179 AAI50180 BC150200 AAI50201 BC150299 BP201387 BP349355 EU794602 ACJ13656 K02765 AAA85332 KC493376 KC493377 M55658 NM_000064 NP_000055
|
| Function |
C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. {ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:9555951}.
|
| Top Pathways |
Phagosome, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection, Complement and coagulation cascades, Pertussis
|