C3

Gene Symbol C3
Entrez Gene 718
Alt Symbol AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
Species Human
Gene Type protein-coding
Description complement component 3
Other Description C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1|C3a anaphylatoxin|acylation-stimulating protein cleavage product|complement C3|complement component C3|complement component C3a|complement component C3b|epididymis secretory sperm binding protein Li 62p|prepro-C3
Swissprots A7E236 P01024
Accessions AAA35722 AAR89906 CAI46844 EAW69070 EAW69071 P01024 AA025232 AI758500 AK094728 AK304071 BAG64978 BC022897 BC063852 BC150179 AAI50180 BC150200 AAI50201 BC150299 BP201387 BP349355 EU794602 ACJ13656 K02765 AAA85332 KC493376 KC493377 M55658 NM_000064 NP_000055
Function C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000250}.
Subcellular Location Secreted.
Tissue Specificity Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. {ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:9555951}.
Top Pathways Phagosome, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection, Complement and coagulation cascades, Pertussis

Activated C3 (I3/15) - sc-47687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

C3 (A-4) - sc-55458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C3 (A-4): sc-55458. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

C3 (C-4) - sc-25298 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C3 (C-4): sc-25298. Western blot analysis of C3 expression in Hep G2 whole cell lysate.

C3 (V-20) - sc-14612 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C3 (V-20): sc-14612. Immunofluorescence staining of methanol-fixed Hep G2 cells showing cytoplasmic localization.

C3 (R-14) - sc-31299 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

C3 (H-300) - sc-20137 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
C3 (H-300): sc-20137. Western blot analysis of C3 expression in Hep G2 whole cell lysate.

C3 (D-19) - sc-31300 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

C3 (B-9) - sc-28294 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C3 (B-9): sc-28294. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse spleen tissue showing cytoplasmic localization.

C3 (2898) - sc-52629 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
C3 (2898): sc-52629. Western blot analysis of C3 expression in Hep G2 whole cell lysate.

C3α (Y-20) - sc-17237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C3α (Y-20): sc-17237. Western blot analysis of C3α expression in THP-1 (A), U-937 (B), T98G (C), CCRF-CEM (D), Daudi (E) and Jurkat (F) whole cell lysates.

C3α (K-19) - sc-14613 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

C3a/α (D17/1) - sc-47689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C3a/α (D17/1): sc-47689. Western blot analysis of the alpha subunit of human complement C3.

C3a/α (K13/16) - sc-47688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
C3a/α (K13/16): sc-47688. Western blot analysis of the alpha subunit of human complement C3.

C3d (003-05) - sc-58928 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
C3d (003-05): sc-58928. Western blot analysis of C3d expression in Hep G2 whole cell lysate.

Anti-C3 / C3a antibody - ab48580 from Abcam

Prices $370.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-C3 / C3a antibody [2898] - ab11874 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2898
All lanes : Anti-C3 / C3a antibody [2898] (ab11874) at 1/200 dilutionLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lane 2 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-C3 / C3a antibody [474] - ab11872 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 474
Lanes 1 & 4 : Anti-C3 / C3a antibody [474] (ab11872) at 1/250 dilution (in 2% BSA for 3 hours at 4°C)Lanes 2 & 5 : Anti-C3 / C3a antibody [474] (ab11872) at 1/500 dilution (in 2% BSA for 3 hours at 4°C)Lanes 3 & 6 : Anti-C3 / C3a antibody [474] (ab11872) at 1/1000 dilution (in 2% BSA for 3 hours at 4°C)Lane 1 : Human serumLane 2 : Human serumLane 3 : Human serumLane 4 : Human serumLane 5 : Human serumLane 6 : Human serumLysates/proteins at 20 µg per lane.SecondaryAn HRP-conjugated Sheep anti-mouse polyclonal at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-C3 / C3a antibody [EPR2987(2)(ABC)(B)] - ab171080 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2987(2)(ABC)(B)
All lanes : Anti-C3 / C3a antibody [EPR2987(2)(ABC)(B)] (ab171080) at 1/1000 dilutionLane 1 : Human plasma lysateLane 2 : Human fetal liver tissue lysateLane 3 : Human fetal kidney tissue lysateLane 4 : HepG2 cell lysateLane 5 : Human milk lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit at 1/2000 dilution

Anti-C3 / C3b antibody [755] - ab11871 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 755
ab11871 staining C3 / C3b in human tonsil tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde; antigen retrieval was by heat mediation. Samples were incubated with primary antibody (1/100) for 32 minutes at 37°C. An undiluted biotin-conjugated goat anti-mouse IgG polyclonal was used as the secondary antibody.See Abreview

Anti-C3 / C3b antibody - BSA and Azide free - ab182948 from Abcam

Prices $370.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-C3 antibody - ab97462 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-C3 antibody (ab97462) at 1/1500 dilution + HepG2 whole cell lysate at 30 µg

Anti-C3 antibody - ab14232 from Abcam

Prices $382.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Direct ELISA test (x axis: protein concentration in ug/ml; y axis: absorbance at 405 nm). Human plasma C3 protein was used as test antigen with ab14232 at a concentration of 0.1 ug/ml.

Anti-C3 antibody - ab48611 from Abcam

Prices $379.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab48611 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab48611, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-C3 antibody - ab129945 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of C3 staining in Human normal Kidney formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab129945, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-C3 antibody - ab189103 from Abcam

Prices $376.00
Sizes 1 ml
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal, adipocytes labeling C3 with ab189103 at 1/200 dilution.
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