NR4A1
| Gene Symbol | NR4A1 |
|---|---|
| Entrez Gene | 3164 |
| Alt Symbol | GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 4, group A, member 1 |
| Other Description | ST-59|TR3 orphan receptor|early response protein NAK1|growth factor-inducible nuclear protein N10|hormone receptor|nerve growth factor IB nuclear receptor variant 1|nuclear hormone receptor NUR/77|nuclear receptor subfamily 4 group A member 1|orphan nuclear receptor HMR|orphan nuclear receptor TR3|steroid receptor TR3|testicular receptor 3 |
| Swissprots | Q6IBU8 Q15627 B4DML7 P22736 Q53Y00 |
| Accessions | CBH19838 EAW58222 EAW58223 EAW58224 EAW58225 EAW58226 EAW58227 EAW58228 P22736 AB307717 BAH02308 AK075054 AK075491 AK096816 AK131566 BAD18699 AK297526 BAG59929 AK314437 BAG37048 AL702926 AL831844 CAD38550 BC016147 AAH16147 BG057763 BT007144 AAP35808 CR456704 CAG32985 D49728 BAA08565 D85245 BAA12746 DQ891134 ABM82060 DQ894313 ABM85239 HQ692855 ADZ17366 L13740 AAA36763 XM_005268822 XP_005268879 XM_005268824 XP_005268881 XM_006719363 XP_006719426 XM_006719364 XP_006719427 XM_011538250 XP_011536552 XM_011538251 XP_011536553 NM_001202233 NP_001189162 NM_001202234 NP_001189163 NM_002135 NP_002126 NM_173157 NP_775180 NM_173158 |
| Function | Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. {ECO:0000250, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}. |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Fetal muscle and adult liver, brain and thyroid. |
| Top Pathways | MAPK signaling pathway, PI3K-Akt signaling pathway |
Nur77 CRISPR/Cas9 KO Plasmid (h) - sc-418320 from Santa Cruz Biotechnology
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Nur77 HDR Plasmid (h) - sc-418320-HDR from Santa Cruz Biotechnology
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Nur77 Double Nickase Plasmid (h) - sc-418320-NIC from Santa Cruz Biotechnology
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Nur77 Double Nickase Plasmid (h2) - sc-418320-NIC-2 from Santa Cruz Biotechnology
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Nur77 CRISPR Activation Plasmid (h) - sc-418320-ACT from Santa Cruz Biotechnology
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Nur77 CRISPR Activation Plasmid (h2) - sc-418320-ACT-2 from Santa Cruz Biotechnology
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Nur77 Lentiviral Activation Particles (h) - sc-418320-LAC from Santa Cruz Biotechnology
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Nur77 Lentiviral Activation Particles (h2) - sc-418320-LAC-2 from Santa Cruz Biotechnology
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Nur77 siRNA (h) - sc-36109 from Santa Cruz Biotechnology
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Nur77 shRNA Plasmid (h) - sc-36109-SH from Santa Cruz Biotechnology
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Nur77 shRNA (h) Lentiviral Particles - sc-36109-V from Santa Cruz Biotechnology
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NGFI-B alpha/Nur77/NR4A1 RNAi - H00003164-R01 from Novus Biologicals
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NGFI-B alpha/Nur77/NR4A1 RNAi - H00003164-R03 from Novus Biologicals
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NGFI-B alpha/Nur77/NR4A1 RNAi - H00003164-R02 from Novus Biologicals
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MISSION® esiRNA - EHU157231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1377 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1377 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04766 from Sigma-Aldrich
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NR4A1 siRNA (Human) - CRH2160 from Cohesion Biosciences
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shRNA set against Human NR4A1 (NM_002135.4) - SHH354836 from Creative biogene
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Nur77 siRNA (h2) - sc-156146 from Santa Cruz Biotechnology
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Nur77 shRNA Plasmid (h2) - sc-156146-SH from Santa Cruz Biotechnology
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Nur77 shRNA (h2) Lentiviral Particles - sc-156146-V from Santa Cruz Biotechnology
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