NR4A1

Gene Symbol NR4A1
Entrez Gene 3164
Alt Symbol GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 4, group A, member 1
Other Description ST-59|TR3 orphan receptor|early response protein NAK1|growth factor-inducible nuclear protein N10|hormone receptor|nerve growth factor IB nuclear receptor variant 1|nuclear hormone receptor NUR/77|nuclear receptor subfamily 4 group A member 1|orphan nuclear receptor HMR|orphan nuclear receptor TR3|steroid receptor TR3|testicular receptor 3
Swissprots Q6IBU8 Q15627 B4DML7 P22736 Q53Y00
Accessions CBH19838 EAW58222 EAW58223 EAW58224 EAW58225 EAW58226 EAW58227 EAW58228 P22736 AB307717 BAH02308 AK075054 AK075491 AK096816 AK131566 BAD18699 AK297526 BAG59929 AK314437 BAG37048 AL702926 AL831844 CAD38550 BC016147 AAH16147 BG057763 BT007144 AAP35808 CR456704 CAG32985 D49728 BAA08565 D85245 BAA12746 DQ891134 ABM82060 DQ894313 ABM85239 HQ692855 ADZ17366 L13740 AAA36763 XM_005268822 XP_005268879 XM_005268824 XP_005268881 XM_006719363 XP_006719426 XM_006719364 XP_006719427 XM_011538250 XP_011536552 XM_011538251 XP_011536553 NM_001202233 NP_001189162 NM_001202234 NP_001189163 NM_002135 NP_002126 NM_173157 NP_775180 NM_173158
Function Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. {ECO:0000250, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Fetal muscle and adult liver, brain and thyroid.
Top Pathways MAPK signaling pathway, PI3K-Akt signaling pathway

Phospho-Nur77 (Ser351) (D22G5) Rabbit mAb - 5095 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D22G5
Western blot analysis of extracts from Jurkat cells, untreated or treated with TPA #4174 and calcium ionophore A23187 for 4 hours, using Phospho-Nur77 (Ser351) (D22G5) Rabbit mAb. Antibody phospho-specificity was confirmed by pre-incubating the antibody with either a phosphorylated site-specific peptide to block the signal or a non-phosphorylated site-specific peptide that does not block the signal.

Nur77 (D63C5) XP ® Rabbit mAb - 3960 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D63C5
Western blot analysis of extracts from COS-7 cells, untransfected (-) or transfected (+) with a human Nur77 construct, using Nur77 (D63C5) XP ® Rabbit mAb.

Nur77 Antibody - 3562 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Nur77 (P15) Antibody - 3559 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Nur77 (C-5) - sc-365113 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Nur77 phosphorylation in non-transfected: sc-110760 (A,D), untreated human Nur77 transfected: sc-112240 (B,E) and lambda protein phosphatase (sc-200312A) treated human Nur77 transfected: sc-112240 (C,F) 293 whole cell lysates. Antibodies tested include p-Nur77 (Ser 341)-R: sc-16991-R (A,B,C) and Nur77 (C-5): sc-365113 (D,E,F).

Nur77 (E-6) - sc-166166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Nur77 (E-6): sc-166166. Western blot analysis of Nur77 expression in non-transfected: sc-117752 (A) and mouse Nur77 transfected: sc-122180 (B) 293T whole cell lysates.

Nur77 (C-19) - sc-7013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Nur77 (M-210) - sc-5569 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Nur77 (M-210): sc-5569. Western blot analysis of human recombinant Nur77 fusion protein.

Nur77 (N-19) - sc-7014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Nur77 (N-19): sc-7014. Western blot analysis of Nur77 expression in human Nur77 transfected: sc-112240 (A) and non-transfected: sc-110760 (B) 293 whole cell lysates.

Nur77 (NR4AB9G12) - sc-81344 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Nur77 (NR4AB9G12): sc-81344. Western blot analysis of Nur77 expression in non-transfected: sc-117752 (A) and human Nur77 transfected: sc-110000 (B) 293T whole cell lysates.

p-Nur77 (Ser 341) - sc-16991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Nur77 phosphorylation in non-transfected: sc-110760 (A,D), untreated human Nur77 transfected: sc-112240 (B,E) and lambda protein phosphatase (sc-200312A) treated human Nur77 transfected: sc-112240 (C,F) 293 whole cell lysates. Antibodies tested include p-Nur77 (Ser 341)-R: sc-16991-R (A,B,C) and Nur77 (C-5): sc-365113 (D,E,F).

p-Nur77 (Ser 351) - sc-16992 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NUR77 (phospho S351) antibody - ab111962 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111962 at 1/50 dilution staining NUR77 in paraffin-embedded Human Colon carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-NUR77 antibody - ab73982 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NUR77 antibody (ab73982) at 1/500 dilutionLane 1 : Extracts from COS-7 cellsLane 2 : Extracts from COS-7 cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-NUR77 antibody [EPR3209] - ab109180 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3209
All lanes : Anti-NUR77 antibody [EPR3209] (ab109180) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HepG2 cell lysateLysates/proteins at 10 µg per lane.

Anti-NUR77 antibody [H1648] - ab41913 from Abcam

Prices $372.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone H1648

Anti-NUR77 antibody - ChIP Grade - ab13851 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of NUR77 in 15 ugs of NIH3T3 cell lysate using ab13851 at 1:500 dilution.

Anti-NR4A1 / NUR77 Antibody - LS-C73799 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-NR4A1 / NUR77 Antibody (N-Terminus) - LS-C31311 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-NR4A1 / NUR77 Antibody - LS-C122193 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-NR4A1 / NUR77 Antibody (clone 12.14, PE) - LS-C105819 from LifeSpan Bioscience

Prices $245.00, $355.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 12.14
Surface staining of unstimulated thymocytes (left) and 2-hr PMA/Iono-stimulated C57Bl/6 thymocytes (right) with APC anti-mouse CD4 (GK1.5) (LS-C107336) followed by intracellular staining with 0.5 ug of PE anti-mouse Nur77 (12.14) using Foxp3 buffers. Total viable cells were used for analysis.

Anti-NR4A1 / NUR77 Antibody (N-Terminus, clone EPR3209) - LS-C105472 from LifeSpan Bioscience

Prices $480.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3209
Western blot analysis on (A) SH-SY5Y and (B) HepG2 on cell lysates using anti-Nur77 antibody (LS-C105472).

Anti-NR4A1 / NUR77 Antibody (Ser351) - LS-C100016 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of NR4A1 (arrow) using rabbit polyclonal NR4A1 Antibody (S351). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NR4A1 gene (Lane 2) (Origene Technologies).

Anti-NR4A1 / NUR77 Antibody (clone 357) - LS-C107089 from LifeSpan Bioscience

Prices $225.00, $335.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 357
Western Blot of PMA and ionomycin-stimulated (lane 1) and unstimulated (lane 2) mouse thymocytes with 5 ug/mL anti-mouse Nur77 antibody. The band was visualized using HRP-conjugated rat anti-mouse IgG.

Anti-NR4A1 / NUR77 Antibody (phospho-Ser351) - LS-C97045 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot of Phospho-NR4A1-S351 polyclonal antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5ug per ml. P-antibody: phospho-antibody; P-Peptide: phospho-peptide; NP-Peptide: non-phospho-peptide.
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