| Gene Symbol |
DPH1
|
| Entrez Gene |
1801
|
| Alt Symbol |
DPH2L, DPH2L1, OVCA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diphthamide biosynthesis 1
|
| Other Description |
DPH-like 1|DPH1 homolog|DPH2-like 1|candidate tumor suppressor in ovarian cancer 1|diphthamide biosynthesis protein 1|diphthamide biosynthesis protein 2 homolog-like 1|diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1|diptheria toxin resistance protein required for diphthamide biosynthesis-like 1|ovarian cancer-associated gene 1 protein|ovarian tumor suppressor candidate 1
|
| Swissprots |
Q9BTW7 Q16439 Q9BZG8 D3DTI3 Q9UCY0 Q4VBA2
|
| Accessions |
EAW90566 EAW90567 EAW90569 Q9BZG8 AF321876 AAK13428 AK090530 BAG52179 AK098268 AK297947 BAG60262 AK314015 BAG36726 AL580693 BC003099 AAH03099 BC013205 BC096086 BC096087 BC096088 AAH96088 BC096089 BP417755 BT019878 AAV38681 DQ891858 ABM82784 DQ895047 ABM85973 S81752 AAB36297 U34880 AAD10198 NM_001383 NP_001374
|
| Function |
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10519411}. Cytoplasm {ECO:0000269|PubMed:10519411}. Note=Punctate, primarily perinuclear localization.
|
| Tissue Specificity |
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors. {ECO:0000269|PubMed:10519411, ECO:0000269|PubMed:8616839}.
|