DPH1

Gene Symbol DPH1
Entrez Gene 1801
Alt Symbol DPH2L, DPH2L1, OVCA1
Species Human
Gene Type protein-coding
Description diphthamide biosynthesis 1
Other Description DPH-like 1|DPH1 homolog|DPH2-like 1|candidate tumor suppressor in ovarian cancer 1|diphthamide biosynthesis protein 1|diphthamide biosynthesis protein 2 homolog-like 1|diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1|diptheria toxin resistance protein required for diphthamide biosynthesis-like 1|ovarian cancer-associated gene 1 protein|ovarian tumor suppressor candidate 1
Swissprots Q9BTW7 Q16439 Q9BZG8 D3DTI3 Q9UCY0 Q4VBA2
Accessions EAW90566 EAW90567 EAW90569 Q9BZG8 AF321876 AAK13428 AK090530 BAG52179 AK098268 AK297947 BAG60262 AK314015 BAG36726 AL580693 BC003099 AAH03099 BC013205 BC096086 BC096087 BC096088 AAH96088 BC096089 BP417755 BT019878 AAV38681 DQ891858 ABM82784 DQ895047 ABM85973 S81752 AAB36297 U34880 AAD10198 NM_001383 NP_001374
Function Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10519411}. Cytoplasm {ECO:0000269|PubMed:10519411}. Note=Punctate, primarily perinuclear localization.
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors. {ECO:0000269|PubMed:10519411, ECO:0000269|PubMed:8616839}.

OVCA1 CRISPR/Cas9 KO Plasmid (h) - sc-410763 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OVCA1 HDR Plasmid (h) - sc-410763-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OVCA1 Double Nickase Plasmid (h) - sc-410763-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OVCA1 Double Nickase Plasmid (h2) - sc-410763-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OVCA1 CRISPR Activation Plasmid (h) - sc-410763-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OVCA1 CRISPR Activation Plasmid (h2) - sc-410763-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OVCA1 Lentiviral Activation Particles (h) - sc-410763-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OVCA1 Lentiviral Activation Particles (h2) - sc-410763-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OVCA1 siRNA (h) - sc-62727 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OVCA1 shRNA Plasmid (h) - sc-62727-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OVCA1 shRNA (h) Lentiviral Particles - sc-62727-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OVCA1 RNAi - H00001801-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU112951 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7450 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7450 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DPH1 siRNA (Human) - CRH1253 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DPH1 - MBS8232075 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DPH1 (NM_001383.3) - SHH280557 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DPH1(NM_001383.3) - SHG208241 from Creative biogene

Category siRNA
Species Reactivities Human

Human DPH1 siRNA - orb261755 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DPH1 shRNA Plasmid (Human) - CHH1253 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DPH1 miRNA 3'UTR clone - MiUTR1H-02964 from Creative biogene

Species Reactivities Human
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