DPH1

Gene Symbol DPH1
Entrez Gene 1801
Alt Symbol DPH2L, DPH2L1, OVCA1
Species Human
Gene Type protein-coding
Description diphthamide biosynthesis 1
Other Description DPH-like 1|DPH1 homolog|DPH2-like 1|candidate tumor suppressor in ovarian cancer 1|diphthamide biosynthesis protein 1|diphthamide biosynthesis protein 2 homolog-like 1|diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1|diptheria toxin resistance protein required for diphthamide biosynthesis-like 1|ovarian cancer-associated gene 1 protein|ovarian tumor suppressor candidate 1
Swissprots Q9BTW7 Q16439 Q9BZG8 D3DTI3 Q9UCY0 Q4VBA2
Accessions EAW90566 EAW90567 EAW90569 Q9BZG8 AF321876 AAK13428 AK090530 BAG52179 AK098268 AK297947 BAG60262 AK314015 BAG36726 AL580693 BC003099 AAH03099 BC013205 BC096086 BC096087 BC096088 AAH96088 BC096089 BP417755 BT019878 AAV38681 DQ891858 ABM82784 DQ895047 ABM85973 S81752 AAB36297 U34880 AAD10198 NM_001383 NP_001374
Function Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10519411}. Cytoplasm {ECO:0000269|PubMed:10519411}. Note=Punctate, primarily perinuclear localization.
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors. {ECO:0000269|PubMed:10519411, ECO:0000269|PubMed:8616839}.

OVCA1 (C-18) - sc-54641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OVCA1 (H-300) - sc-67199 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OVCA1 (H-300): sc-67199. Western blot analysis of OVCA1 expression in mouse ovary (A) and rat ovary (B) tissue extracts.

OVCA1 (S-15) - sc-54643 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OVCA1 (Y-17) - sc-54644 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OVCA1 (Y-17): sc-54644. Western blot analysis of human recombinant OVCA1 fusion protein.

OVCA1 (6E93) - sc-101248 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
OVCA1 (6E93): sc-101248. Western blot analysis of OVCA1 expression in HeLa whole cell lysate.

Anti-OVCA1 antibody - ab54777 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-OVCA1 antibody - ab129692 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-OVCA1 antibody (ab129692) at 1/100 dilution + A375 cell line lysates at 35 µg

Anti-OVCA1 antibody - ab40733 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 antibody [EPR15342] - C-terminal - ab185960 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15342
Western blot analysis of immunoprecipitation pellet from SKBR3 cell lysate immunoprecipitated using ab185960 at 1/50 dilution (lane 1) or PBS control (lane 2).Secondary: Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1500 dilution.

Anti-OVCA1 / DPH1 Antibody - LS-C82325 from LifeSpan Bioscience

Prices $380.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 / DPH1 Antibody (aa272-321) - LS-C81683 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MCF7 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-OVCA1 / DPH1 Antibody (aa216-325, clone 10B2757, Azide-free) - LS-C183575 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10B2757

Anti-OVCA1 / DPH1 Antibody (aa384-412, AP) - LS-C222208 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 / DPH1 Antibody (aa384-412, APC) - LS-C222210 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 / DPH1 Antibody (aa384-412, Biotin) - LS-C222211 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 / DPH1 Antibody (aa384-412, FITC) - LS-C222212 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 / DPH1 Antibody (aa384-412, Azide-free, HRP) - LS-C222213 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 / DPH1 Antibody (aa384-412, PE) - LS-C222214 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 / DPH1 Antibody (aa383-412) - LS-C320939 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OVCA1 / DPH1 Antibody (aa35-84) - LS-C116434 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DPH1 / OVCA1 antibody LS-C116434 Western blot of RPMI-8226 cell lysate.

Anti-OVCA1 / DPH1 Antibody (aa384-412) - LS-C167514 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DPH1 Antibody western blot of A375 cell line lysates (35 ug/lane). The DPH1 antibody detected the DPH1 protein (arrow).

Anti-OVCA1 / DPH1 Antibody (clone 2C5) - LS-C197072 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C5
Immunofluorescence of monoclonal antibody to DPH1 on HeLa cell. [antibody concentration 10 ug/ml]

Anti-OVCA1 / DPH1 Antibody - LS-C82324 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OVCA1 Antibody - NBP1-56693 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: OVCA1 Antibody [NBP1-56693] - MCF-7 whole cell lysates, concentration 0.2-1 ug/ml.

OVCA1 Antibody - NBP1-57711 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: OVCA1 Antibody [NBP1-57711] - RPMI 8226 cell lysate, concentration 0.2-1 ug/ml.
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