| Gene Symbol |
GPR183
|
| Entrez Gene |
1880
|
| Alt Symbol |
EBI2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 183
|
| Other Description |
EBV-induced G-protein coupled receptor 2|Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)|G-protein coupled receptor 183|epstein-Barr virus-induced G-protein coupled receptor 2
|
| Swissprots |
B2R8N5 Q53F99 P32249 Q5JUH7
|
| Accessions |
CCF77011 EAX09018 EAX09019 P32249 AI740732 AK223390 BAD97110 AK292091 BAF84780 AK313443 BAG36232 AW402166 AW574697 AW575283 BC020752 AAH20752 DQ891368 ABM82294 DQ894548 ABM85474 L08177 AAA35924 NM_004951 NP_004942
|
| Function |
Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2). {ECO:0000250, ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108}; Multi-pass membrane protein {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108}.
|
| Tissue Specificity |
Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain. {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:8383238}.
|