Gene Symbol | GPR183 |
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Entrez Gene | 1880 |
Alt Symbol | EBI2 |
Species | Human |
Gene Type | protein-coding |
Description | G protein-coupled receptor 183 |
Other Description | EBV-induced G-protein coupled receptor 2|Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)|G-protein coupled receptor 183|epstein-Barr virus-induced G-protein coupled receptor 2 |
Swissprots | B2R8N5 Q53F99 P32249 Q5JUH7 |
Accessions | CCF77011 EAX09018 EAX09019 P32249 AI740732 AK223390 BAD97110 AK292091 BAF84780 AK313443 BAG36232 AW402166 AW574697 AW575283 BC020752 AAH20752 DQ891368 ABM82294 DQ894548 ABM85474 L08177 AAA35924 NM_004951 NP_004942 |
Function | Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2). {ECO:0000250, ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108}; Multi-pass membrane protein {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108}. |
Tissue Specificity | Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes. Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain. {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:8383238}. |
Human EBV Induced Gene 2 full length protein - ab158331 from Abcam
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GPR183 / EBI2 Antibody Blocking Peptide - LS-E28995 from LifeSpan Bioscience
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GPR183 / EBI2 Antibody Blocking Peptide - LS-E28971 from LifeSpan Bioscience
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GPR183 / EBI2 Antibody Blocking Peptide - LS-E28980 from LifeSpan Bioscience
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GPR183 / EBI2 Antibody Blocking Peptide - LS-E27547 from LifeSpan Bioscience
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GPR183 / EBI2 Antibody Blocking Peptide - LS-E24100 from LifeSpan Bioscience
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Recombinant Human EBI2/GPR183 Protein - H00001880-P01 from Novus Biologicals
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EBV Induced Gene 2 Peptide - AC21-2369-P from Abcore
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EBI2 / GPR183 - H00001880-G01 from Acris Antibodies
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EBI2 / GPR183 - H00001880-P01-10 from Acris Antibodies
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EBI2 / GPR183 - H00001880-P01-25 from Acris Antibodies
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GPR183 Peptide - 42-331P from ProSci
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GPR183 fusion protein - Ag3035 from Proteintech Group
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Recombinant Human GPR183, GST-tagged - GPR183-13469H from Creative Biomart
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Recombinant Human GPR183 - GPR183-765H from Creative Biomart
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Recombinant Human EBI2/GPR183 Protein - H00001880-G01 from Novus Biologicals
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GPR183, Peptide - MBS427538 from MyBioSource
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GPR183 Peptide, Human - M34GP06558H from Creative Peptides
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G-protein coupled receptor 183 (GPR183), Recombinant Protein - MBS954512 from MyBioSource
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G-protein coupled receptor 183 (GPR183), Recombinant Protein - MBS7016162 from MyBioSource
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GPR183 Immunizing peptide - orb59722 from Biorbyt
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