FGA

Gene Symbol	FGA
Entrez Gene	2243
Alt Symbol	Fib2
Species	Human
Gene Type	protein-coding
Description	fibrinogen alpha chain
Other Description	fibrinogen, A alpha polypeptide
Swissprots	Q9UCH2 Q9BX62 D3DP14 A8K3E4 P02671 D3DP15 Q4QQH7
Accessions	AAA17055 AAA17056 AAB47117 AAK31372 AAK31373 BAC55116 CDL78900 EAX04924 EAX04925 EAX04926 EAX04927 EAX04928 P02671 AK290559 BAF83248 AL531808 AL579998 BC020764 AAH20764 BC070246 AAH70246 BC098280 AAH98280 BC099706 AAH99706 BC099720 AAH99720 BC101935 AAI01936 BC105803 AAI05804 BG565064 BQ064506 BX494953 CB122305 CD608675 J00127 AAA52426 J00128 AAA52427 K02272 AAA52428 M26878 AAA52444 M58569 AAC97142 NM_000508 NP_000499 NM_021871 NP_068657
Function	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
Subcellular Location	Secreted.
Tissue Specificity	Plasma.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Fibrinogen Human ELISA Kit - ab108842 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 0.16 µg/ml Range 0.165 µg/ml - 40 µg/ml

Fibrinogen Human ELISA Kit - ab108841 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity = 1 ng/ml Range 1.25 ng/ml - 80 ng/ml

Fibrinogen Human SimpleStep ELISATM Kit - ab171578 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 139 pg/ml Range 0.14 ng/ml - 100 ng/ml

Human FGA / Fibrinogen Alpha ELISA Kit (Sandwich ELISA) - LS-F4467 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 15.63 ng/ml Range 15.63-1000 ng/ml

Rat FGA / Fibrinogen Alpha ELISA Kit (Sandwich ELISA) - LS-F5700 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.57 ng/ml Range 15.63-1000 ng/ml

Mouse FGA / Fibrinogen Alpha EIA Kit - LS-F5699 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 8.58 ng/ml Range 24.69 - 2000 ng/ml

Human FGA / Fibrinogen Alpha ELISA Kit (Sandwich ELISA) - LS-F11466 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 15.63-1000 ng/ml

Rabbit FGA / Fibrinogen Alpha ELISA Kit - LS-F11468 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 Range 0.156 - 10 ng/ml

Bovine FGA / Fibrinogen Alpha ELISA Kit (Sandwich ELISA) - LS-F11469 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 7.8 Range 15.63-1000 ng/ml

Human FGA / Fibrinogen Alpha Chain ELISA Kit - RAB0648 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Fibrinogen Alpha, FGa, Human, ELISA Kit - E-EL-H2110 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 3.75 Range 6.25-400ng/mL

Fibrinogen alpha chain (FGA), Human, ELISA Kit - E01F0366 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Fibrinogen alpha chain, FGA, Human, ELISA Kit - E1237h from ARP American Research Products Category ELISA Kit Prices $636.00 Sizes 96 t Range 0.78-50 ng/mL

Fibrinogen Alpha chain, FGA, Mouse, ELISA Kit - E-EL-M0494 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000ng/mL

Fibrinogen Alpha, Fga, Rat, ELISA Kit - E-EL-R0376 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

Fibrinogen Alpha, FGa, Rabbit, ELISA Kit - E-EL-RB1817 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Fibrinogen Alpha, FGa, Chicken, ELISA Kit - E-EL-Ch1462 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Fibrinogen Alpha, FGa, Porcine, ELISA Kit - E-EL-P1482 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Fibrinogen Alpha, FGa, Monkey, ELISA Kit - E-EL-MK1212 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

FGA (Human) IP-WB Antibody Pair - H00002243-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

FGA (Human) Matched Antibody Pair - H00002243-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

FGA (Human) Matched Antibody Pair - H00002243-AP61 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human D-Dimer ELISA - ELH-DDIMER from RayBiotech Category ELISA Kit Prices $462.00, $832.00, $1,850.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 0.08 pg/ml Range 0.08 pg/ml - 60 pg/ml

fibrinogen alpha chain (FGA), ELISA Kit - MBS7252413 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

fibrinogen alpha chain (FGA), ELISA Kit - MBS7226080 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ug/mL.

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