FGA

Gene Symbol	FGA
Entrez Gene	2243
Alt Symbol	Fib2
Species	Human
Gene Type	protein-coding
Description	fibrinogen alpha chain
Other Description	fibrinogen, A alpha polypeptide
Swissprots	Q9UCH2 Q9BX62 D3DP14 A8K3E4 P02671 D3DP15 Q4QQH7
Accessions	AAA17055 AAA17056 AAB47117 AAK31372 AAK31373 BAC55116 CDL78900 EAX04924 EAX04925 EAX04926 EAX04927 EAX04928 P02671 AK290559 BAF83248 AL531808 AL579998 BC020764 AAH20764 BC070246 AAH70246 BC098280 AAH98280 BC099706 AAH99706 BC099720 AAH99720 BC101935 AAI01936 BC105803 AAI05804 BG565064 BQ064506 BX494953 CB122305 CD608675 J00127 AAA52426 J00128 AAA52427 K02272 AAA52428 M26878 AAA52444 M58569 AAC97142 NM_000508 NP_000499 NM_021871 NP_068657
Function	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
Subcellular Location	Secreted.
Tissue Specificity	Plasma.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active cow Fibrinogen full length protein - ab92827 from Abcam Category Protein Prices $356.00 Sizes 25 mg Source Native Species Bovine

Active mouse Fibrinogen full length protein - ab167791 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Mouse

Active mouse Fibrinogen full length protein - ab92791 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Mouse

Active rat Fibrinogen full length protein - ab168891 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Rat

Active rat Fibrinogen full length protein - ab93072 from Abcam Category Protein Prices $356.00 Sizes 1 mg Source Native Species Rat

Cow Fibrinogen full length protein - ab92812 from Abcam Category Protein Prices $356.00 Sizes 10 mg Source Native Species Bovine

Dog Fibrinogen full length protein - ab92970 from Abcam Category Protein Prices $785.00 Sizes 1 mg Source Native Species Dog

Dog Fibrinogen full length protein - ab93006 from Abcam Category Protein Prices $450.00 Sizes 1 mg Source Native Species Dog

Human Fibrinogen full length protein - ab81752 from Abcam Category Protein Source Native Species Human

Human Fibrinogen full length protein - ab84410 from Abcam Category Protein Source Native Species Human

Human Fibrinogen full length protein - ab92811 from Abcam Category Protein Source Native Species Human

Human Fibrinogen protein fragment - ab62394 from Abcam Category Protein Source Native Species Human

Human Fibrinogen protein fragment - ab62253 from Abcam Category Protein Source Native Species Human

Human Fibrinopeptide A full length protein - ab158432 from Abcam Category Protein Source Wheat germ Species Human

Mouse Fibrinogen full length protein - ab92792 from Abcam Category Protein Source Native Species Mouse

Pig Fibrinogen full length protein - ab92790 from Abcam Category Protein Source Native Species Pig

Pig Fibrinogen full length protein - ab92828 from Abcam Category Protein Source Native Species Pig

Rabbit Fibrinogen full length protein - ab92788 from Abcam Category Protein Source Native Species Rabbit

Rabbit Fibrinogen full length protein - ab92829 from Abcam Category Protein Source Native Species Rabbit

Rat Fibrinogen full length protein - ab92878 from Abcam Category Protein Source Native Species Rat

Sheep Fibrinogen full length protein - ab92787 from Abcam Category Protein Source Native Species Sheep

Sheep Fibrinogen full length protein - ab96790 from Abcam Category Protein Source Native Species Sheep

FGA / Fibrinogen Alpha Antibody Blocking Peptide - LS-E8495 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FGA / Fibrinogen Alpha Antibody Blocking Peptide - LS-E15366 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Fibrinopeptide A Protein - H00002243-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

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