FGA

Gene Symbol	FGA
Entrez Gene	2243
Alt Symbol	Fib2
Species	Human
Gene Type	protein-coding
Description	fibrinogen alpha chain
Other Description	fibrinogen, A alpha polypeptide
Swissprots	Q9UCH2 Q9BX62 D3DP14 A8K3E4 P02671 D3DP15 Q4QQH7
Accessions	AAA17055 AAA17056 AAB47117 AAK31372 AAK31373 BAC55116 CDL78900 EAX04924 EAX04925 EAX04926 EAX04927 EAX04928 P02671 AK290559 BAF83248 AL531808 AL579998 BC020764 AAH20764 BC070246 AAH70246 BC098280 AAH98280 BC099706 AAH99706 BC099720 AAH99720 BC101935 AAI01936 BC105803 AAI05804 BG565064 BQ064506 BX494953 CB122305 CD608675 J00127 AAA52426 J00128 AAA52427 K02272 AAA52428 M26878 AAA52444 M58569 AAC97142 NM_000508 NP_000499 NM_021871 NP_068657
Function	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
Subcellular Location	Secreted.
Tissue Specificity	Plasma.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FGA Gene cDNA Clone - orb143168 from Biorbyt Prices $366.00 Sizes 10 μg Species Human

Human-FGA-cDNA-Clone - DC09135 from Abgent, a WuXi AppTec company Prices $294.30 Sizes 10 µg Species Human Accession BC020764

FGA - MBS1269564 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC099706

FGA - MBS1275742 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC020764

Human FGA cDNA clone(NM_021871.2) - CDFG003417 from Creative Biomart Species Human Accession NM_021871.2

Human FGA cDNA clone(NM_000508.3) - CDFH006806 from Creative Biomart Species Human Accession NM_000508.3

Human FGA ORF clone - CDCL107919 from Creative Biomart Species Human Accession NM_000508

Human FGA ORF clone - CDCL107920 from Creative Biomart Species Human Accession NM_000508

Mouse FGA ORF clone - CDCL107921 from Creative Biomart Species Human Accession NM_000508

Mouse FGA ORF clone - CDCL107922 from Creative Biomart Species Human Accession NM_000508

Human FGA ORF Clone(NM_021871.2) - CDCL163437 from Creative Biomart Species Human Accession NM_021871.2

Human FGA ORF Clone(NM_000508.3) - CDCL163438 from Creative Biomart Species Human Accession NM_000508.3

Human FGA ORF Clone(NM_021871.2) - CDCR307162 from Creative Biomart Species Human Accession NM_021871.2

Human FGA ORF Clone(NM_021871.2) - CDCR307163 from Creative Biomart Species Human Accession NM_021871.2

Human FGA ORF Clone(NM_000508.3) - CDCR336629 from Creative Biomart Species Human Accession NM_000508.3

Human FGA ORF Clone(NM_000508.3) - CDCR336630 from Creative Biomart Species Human Accession NM_000508.3

Human Fibrinogen Gene ORF cDNA clone in cloning vector - HG16000-G from Sino Biological Species Human

Human Fibrinogen Gene ORF cDNA clone expression plasmid, N-His tag - HG16000-NH from Sino Biological Species Human

Human Fibrinogen Gene ORF cDNA clone expression plasmid, C-His tag - HG16000-CH from Sino Biological Species Human

Human Fibrinogen Gene ORF cDNA clone expression plasmid, N-Flag tag - HG16000-NF from Sino Biological Species Human

Human Fibrinogen Gene ORF cDNA clone expression plasmid - HG16000-UT from Sino Biological Species Human

Human Fibrinogen Gene ORF cDNA clone expression plasmid, C-Flag tag - HG16000-CF from Sino Biological Species Human

Human Fibrinogen Gene ORF cDNA clone expression plasmid, N-Myc tag - HG16000-NM from Sino Biological Species Human

Human Fibrinogen Gene ORF cDNA clone expression plasmid, C-Myc tag - HG16000-CM from Sino Biological Species Human

Human Fibrinogen Gene ORF cDNA clone expression plasmid, C-HA tag - HG16000-CY from Sino Biological Species Human

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