FGA
| Gene Symbol | FGA |
|---|---|
| Entrez Gene | 2243 |
| Alt Symbol | Fib2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibrinogen alpha chain |
| Other Description | fibrinogen, A alpha polypeptide |
| Swissprots | Q9UCH2 Q9BX62 D3DP14 A8K3E4 P02671 D3DP15 Q4QQH7 |
| Accessions | AAA17055 AAA17056 AAB47117 AAK31372 AAK31373 BAC55116 CDL78900 EAX04924 EAX04925 EAX04926 EAX04927 EAX04928 P02671 AK290559 BAF83248 AL531808 AL579998 BC020764 AAH20764 BC070246 AAH70246 BC098280 AAH98280 BC099706 AAH99706 BC099720 AAH99720 BC101935 AAI01936 BC105803 AAI05804 BG565064 BQ064506 BX494953 CB122305 CD608675 J00127 AAA52426 J00128 AAA52427 K02272 AAA52428 M26878 AAA52444 M58569 AAC97142 NM_000508 NP_000499 NM_021871 NP_068657 |
| Function | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Plasma. |
| Top Pathways | Complement and coagulation cascades |
Fibrinogen α CRISPR/Cas9 KO Plasmid (h) - sc-400793 from Santa Cruz Biotechnology
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Fibrinogen α HDR Plasmid (h) - sc-400793-HDR from Santa Cruz Biotechnology
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Fibrinogen α Double Nickase Plasmid (h) - sc-400793-NIC from Santa Cruz Biotechnology
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Fibrinogen α Double Nickase Plasmid (h2) - sc-400793-NIC-2 from Santa Cruz Biotechnology
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Fibrinogen α CRISPR Activation Plasmid (h) - sc-400793-ACT from Santa Cruz Biotechnology
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Fibrinogen α CRISPR Activation Plasmid (h2) - sc-400793-ACT-2 from Santa Cruz Biotechnology
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Fibrinogen α Lentiviral Activation Particles (h) - sc-400793-LAC from Santa Cruz Biotechnology
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Fibrinogen α Lentiviral Activation Particles (h2) - sc-400793-LAC-2 from Santa Cruz Biotechnology
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Fibrinogen α siRNA (h) - sc-40409 from Santa Cruz Biotechnology
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Fibrinogen α shRNA Plasmid (h) - sc-40409-SH from Santa Cruz Biotechnology
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Fibrinogen α shRNA (h) Lentiviral Particles - sc-40409-V from Santa Cruz Biotechnology
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Fibrinopeptide A RNAi - H00002243-R01 from Novus Biologicals
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MISSION® esiRNA - EHU091021 from Sigma-Aldrich
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MISSION® esiRNA - EHU098721 from Sigma-Aldrich
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MISSION® esiRNA - EHU100191 from Sigma-Aldrich
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MISSION® esiRNA - EHU140701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8638 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8638 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07620 from Sigma-Aldrich
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FGA siRNA (Human) - CRH1563 from Cohesion Biosciences
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Fibrinopeptide A RNAi - H00002243-R02 from Novus Biologicals
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FGA - MBS8240177 from MyBioSource
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shRNA set against Human FGA (NM_000508.3) - SHH294265 from Creative biogene
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shRNA set against Human FGA(NM_000508.3) - SHH056279 from Creative biogene
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shRNA set against Human FGA(NM_021871.2) - SHH056315 from Creative biogene
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