Gene Symbol |
NRG4
|
Entrez Gene |
145957
|
Alt Symbol |
HRG4
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
neuregulin 4
|
Other Description |
heregulin 4|pro-NRG4|pro-neuregulin-4, membrane-bound isoform
|
Swissprots |
Q8WWG1 A6NIE8
|
Accessions |
EAW99227 EAW99228 Q8WWG1 AK307362 AK311204 AK311507 AM392364 CAL35829 AM392365 CAL35830 AM392366 CAL35831 BC017568 AAH17568 BX538100 CAD98015 CR749519 CAH18333 HQ448724 ADQ33202 NM_138573 NP_612640
|
Function |
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). {ECO:0000250}.
|
Subcellular Location |
Pro-neuregulin-4, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.
|
Top Pathways |
ErbB signaling pathway
|