Gene Symbol | NRG4 |
---|---|
Entrez Gene | 145957 |
Alt Symbol | HRG4 |
Species | Human |
Gene Type | protein-coding |
Description | neuregulin 4 |
Other Description | heregulin 4|pro-NRG4|pro-neuregulin-4, membrane-bound isoform |
Swissprots | Q8WWG1 A6NIE8 |
Accessions | EAW99227 EAW99228 Q8WWG1 AK307362 AK311204 AK311507 AM392364 CAL35829 AM392365 CAL35830 AM392366 CAL35831 BC017568 AAH17568 BX538100 CAD98015 CR749519 CAH18333 HQ448724 ADQ33202 NM_138573 NP_612640 |
Function | Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). {ECO:0000250}. |
Subcellular Location | Pro-neuregulin-4, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}. |
Top Pathways | ErbB signaling pathway |