| Gene Symbol |
SOCS6
|
| Entrez Gene |
9306
|
| Alt Symbol |
CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of cytokine signaling 6
|
| Other Description |
STAT induced STAT inhibitor-4|cytokine-inducible SH2 protein 4|suppressor of cytokine signaling 4
|
| Swissprots |
Q8WUM3 O14544
|
| Accessions |
EAW66522 EAW66523 EAW66524 O14544 AB006968 BAA22538 AF161545 AAF29032 AK024356 BC020082 AAH20082 XM_005266783 XP_005266840 NM_004232 NP_004223
|
| Function |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}.
|
| Top Pathways |
Prolactin signaling pathway
|
![Western Blot: SOCS6 Overexpression Lysate (Adult Normal) [NBL1-16331] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SOCS6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6860_SOCS6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16331-img0002.jpg)