Gene Symbol |
CMBL
|
Entrez Gene |
134147
|
Alt Symbol |
JS-1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
carboxymethylenebutenolidase homolog (Pseudomonas)
|
Other Description |
carboxymethylenebutenolidase homolog|carboxymethylenebutenolidase-like (Pseudomonas)
|
Swissprots |
Q96DG6 Q8TED6 D3DTC7
|
Accessions |
EAX08070 EAX08071 Q96DG6 AJ278125 CAC81950 AK074197 BAB85014 AK315390 BAG37783 BC001573 AAH01573 BX647141 DA628493 HQ447384 ADQ31870 NM_138809 NP_620164
|
Function |
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}.
|
Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:20177059}.
|
Tissue Specificity |
Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level). {ECO:0000269|PubMed:20177059}.
|