Gene Symbol | CMBL |
---|---|
Entrez Gene | 134147 |
Alt Symbol | JS-1 |
Species | Human |
Gene Type | protein-coding |
Description | carboxymethylenebutenolidase homolog (Pseudomonas) |
Other Description | carboxymethylenebutenolidase homolog|carboxymethylenebutenolidase-like (Pseudomonas) |
Swissprots | Q96DG6 Q8TED6 D3DTC7 |
Accessions | EAX08070 EAX08071 Q96DG6 AJ278125 CAC81950 AK074197 BAB85014 AK315390 BAG37783 BC001573 AAH01573 BX647141 DA628493 HQ447384 ADQ31870 NM_138809 NP_620164 |
Function | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:20177059}. |
Tissue Specificity | Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level). {ECO:0000269|PubMed:20177059}. |