Gene Symbol | CMBL |
---|---|
Entrez Gene | 134147 |
Alt Symbol | JS-1 |
Species | Human |
Gene Type | protein-coding |
Description | carboxymethylenebutenolidase homolog (Pseudomonas) |
Other Description | carboxymethylenebutenolidase homolog|carboxymethylenebutenolidase-like (Pseudomonas) |
Swissprots | Q96DG6 Q8TED6 D3DTC7 |
Accessions | EAX08070 EAX08071 Q96DG6 AJ278125 CAC81950 AK074197 BAB85014 AK315390 BAG37783 BC001573 AAH01573 BX647141 DA628493 HQ447384 ADQ31870 NM_138809 NP_620164 |
Function | Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. {ECO:0000269|PubMed:20177059}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:20177059}. |
Tissue Specificity | Widely expressed, with highest levels in liver, followed by kidney, small intestine and colon. Present in liver and intestine (at protein level). {ECO:0000269|PubMed:20177059}. |
CMBL CRISPR/Cas9 KO Plasmid (h) - sc-407870 from Santa Cruz Biotechnology
|
||||||||
CMBL HDR Plasmid (h) - sc-407870-HDR from Santa Cruz Biotechnology
|
||||||||
CMBL Double Nickase Plasmid (h) - sc-407870-NIC from Santa Cruz Biotechnology
|
||||||||
CMBL Double Nickase Plasmid (h2) - sc-407870-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CMBL CRISPR Activation Plasmid (h) - sc-407870-ACT from Santa Cruz Biotechnology
|
||||||||
CMBL CRISPR Activation Plasmid (h2) - sc-407870-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CMBL Lentiviral Activation Particles (h) - sc-407870-LAC from Santa Cruz Biotechnology
|
||||||||
CMBL Lentiviral Activation Particles (h2) - sc-407870-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CMBL siRNA (h) - sc-92035 from Santa Cruz Biotechnology
|
||||||||
CMBL shRNA Plasmid (h) - sc-92035-SH from Santa Cruz Biotechnology
|
||||||||
CMBL shRNA (h) Lentiviral Particles - sc-92035-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU142851 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN6281 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6281 from Sigma-Aldrich
|
||||||||
CMBL siRNA (Human) - CRJ5133 from Cohesion Biosciences
|
||||||||
CMBL - MBS8226501 from MyBioSource
|
||||||||
shRNA set against Human CMBL (NM_138809.3) - SHH265869 from Creative biogene
|
||||||||
shRNA set against Human CMBL(NM_138809.3) - SHG185227 from Creative biogene
|
||||||||
Human CMBL siRNA - orb275634 from Biorbyt
|
||||||||
CMBL shRNA Plasmid (Human) - CHJ5133 from Cohesion Biosciences
|
||||||||
CMBL miRNA 3'UTR clone - MiUTR1H-02243 from Creative biogene
|