TMEM173

Gene Symbol TMEM173
Entrez Gene 340061
Alt Symbol ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING
Species Human
Gene Type protein-coding
Description transmembrane protein 173
Other Description N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner|endoplasmic reticulum IFN stimulator|endoplasmic reticulum interferon stimulator|mitochondrial mediator of IRF3 activation|stimulator of interferon genes protein
Swissprots D6RBX0 Q86WV6 A8K3P6 D6RID9 B6EB35 D6RE01
Accessions EAW62098 EAW62099 EAW62100 Q86WV6 AK095896 AK129800 AK290661 BAF83350 AX775913 CAE11656 BC047779 AAH47779 BE548954 BM149879 BM981219 BU731116 FJ222241 ACI46648 HQ448605 ADQ33083 KF430638 AHB86590 XM_005268445 XP_005268502 XM_011537639 XP_011535941 XM_011537640 XP_011535942 NM_001301738 NP_001288667 NM_198282 NP_938023
Function Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates d
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited.
Tissue Specificity Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25029335}.
Top Pathways RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway

Transmembrane protein 173 (TMEM173), Human, ELISA Kit - E01T0704 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7212324 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7202857 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7237945 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7200105 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7216515 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7228810 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7237315 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7215072 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7219681 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7221743 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane protein 173 (TMEM173), ELISA Kit - MBS7252725 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

ELISA Kit for Transmembrane Protein 173 (TMEM173) - SEN011Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Transmembrane Protein 173 (TMEM173) - SEN011Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.062ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human TMEM173 ELISA Kit - E039232 from Biobool

Category ELISA Kit
Sensitivity 0.1 ng/mL.

TMEM173 ELISA Kit (Human) (OKCD00623) - OKCD00623 from Aviva Systems Biology

Category ELISA Kit
Prices $585.00
Sizes 96 wells
Sensitivity < 0.062 ng/mL
Range 0.156-10 ng/mL

anti-TMEM173 / STING antibody - ARG56280 from Arigo Biolaboratories

Category ELISA Kit

Human TMEM173 / STING ELISA Kit (Sandwich ELISA) - LS-F39117 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 0.062
Range 0.156-10 ng/ml
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