| Gene Symbol | TMEM173 |
|---|---|
| Entrez Gene | 340061 |
| Alt Symbol | ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING |
| Species | Human |
| Gene Type | protein-coding |
| Description | transmembrane protein 173 |
| Other Description | N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner|endoplasmic reticulum IFN stimulator|endoplasmic reticulum interferon stimulator|mitochondrial mediator of IRF3 activation|stimulator of interferon genes protein |
| Swissprots | D6RBX0 Q86WV6 A8K3P6 D6RID9 B6EB35 D6RE01 |
| Accessions | EAW62098 EAW62099 EAW62100 Q86WV6 AK095896 AK129800 AK290661 BAF83350 AX775913 CAE11656 BC047779 AAH47779 BE548954 BM149879 BM981219 BU731116 FJ222241 ACI46648 HQ448605 ADQ33083 KF430638 AHB86590 XM_005268445 XP_005268502 XM_011537639 XP_011535941 XM_011537640 XP_011535942 NM_001301738 NP_001288667 NM_198282 NP_938023 |
| Function | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates d |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited. |
| Tissue Specificity | Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25029335}. |
| Top Pathways | RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway |
TMEM173 CRISPR/Cas9 KO Plasmid (h) - sc-403148 from Santa Cruz Biotechnology
|
||||||||
TMEM173 HDR Plasmid (h) - sc-403148-HDR from Santa Cruz Biotechnology
|
||||||||
TMEM173 Double Nickase Plasmid (h) - sc-403148-NIC from Santa Cruz Biotechnology
|
||||||||
TMEM173 Double Nickase Plasmid (h2) - sc-403148-NIC-2 from Santa Cruz Biotechnology
|
||||||||
TMEM173 CRISPR Activation Plasmid (h) - sc-403148-ACT from Santa Cruz Biotechnology
|
||||||||
TMEM173 CRISPR Activation Plasmid (h2) - sc-403148-ACT-2 from Santa Cruz Biotechnology
|
||||||||
TMEM173 Lentiviral Activation Particles (h) - sc-403148-LAC from Santa Cruz Biotechnology
|
||||||||
TMEM173 Lentiviral Activation Particles (h2) - sc-403148-LAC-2 from Santa Cruz Biotechnology
|
||||||||
TMEM173 siRNA (h) - sc-92042 from Santa Cruz Biotechnology
|
||||||||
TMEM173 shRNA Plasmid (h) - sc-92042-SH from Santa Cruz Biotechnology
|
||||||||
TMEM173 shRNA (h) Lentiviral Particles - sc-92042-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU133481 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN21543 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21543 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR02019 from Sigma-Aldrich
|
||||||||
TMEM173 siRNA (Human) - CRJ7323 from Cohesion Biosciences
|
||||||||
TMEM173 - MBS8240246 from MyBioSource
|
||||||||
shRNA set against Human TMEM173 (NM_198282.2) - SHH429572 from Creative biogene
|
||||||||
Human TMEM173 siRNA - orb277824 from Biorbyt
|
||||||||
TMEM173 shRNA Plasmid (Human) - CHJ7323 from Cohesion Biosciences
|
||||||||
TMEM173 miRNA 3'UTR clone - MiUTR3H-12405 from Creative biogene
|