TMEM173

Gene Symbol TMEM173
Entrez Gene 340061
Alt Symbol ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING
Species Human
Gene Type protein-coding
Description transmembrane protein 173
Other Description N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner|endoplasmic reticulum IFN stimulator|endoplasmic reticulum interferon stimulator|mitochondrial mediator of IRF3 activation|stimulator of interferon genes protein
Swissprots D6RBX0 Q86WV6 A8K3P6 D6RID9 B6EB35 D6RE01
Accessions EAW62098 EAW62099 EAW62100 Q86WV6 AK095896 AK129800 AK290661 BAF83350 AX775913 CAE11656 BC047779 AAH47779 BE548954 BM149879 BM981219 BU731116 FJ222241 ACI46648 HQ448605 ADQ33083 KF430638 AHB86590 XM_005268445 XP_005268502 XM_011537639 XP_011535941 XM_011537640 XP_011535942 NM_001301738 NP_001288667 NM_198282 NP_938023
Function Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates d
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited.
Tissue Specificity Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25029335}.
Top Pathways RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway

D. melanogaster Aubergine / Sting peptide - ab19076 from Abcam

Category Peptide
Prices $181.00
Sizes 100 µg

TMEM173 / STING Antibody Blocking Peptide - LS-E30743 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

TMEM173 / STING Antibody Blocking Peptide - LS-E21597 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

TMEM173 / STING Antibody Blocking Peptide - LS-E10295 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

TMEM173 / STING Antibody Blocking Peptide - LS-E10331 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

STING/TMEM173 Peptide - NBP1-77055PEP from Novus Biologicals

Category Peptide
Prices $149.00
Sizes 50 µg
Species Human

TM173-Antibody-C-term-Blocking-Peptide - BP9807b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

TM173-Antibody-C-term-Blocking-Peptide - BP9747b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

MPYS Peptide - GTX85266-PEP from GeneTex

Category Peptide
Prices $149.00
Sizes 50 μg
Species Human

TMEM173 Blocking Peptide - 33R-2109 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

Human TMEM173 Protein - abx069447 from Abbexa

Category Protein
Source E.coli
Species Human

TMEM173 / STING Control Peptide - AP30565CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

Transmembrane Protein 173 (TMEM173), Human - 20-9542 from ARP American Research Products

Category Protein
Prices $469.00
Sizes 50 µg
Source E.coli
Species Human

MPYS Peptide - 5269P from ProSci

Category Peptide
Species Human

TMEM173 fusion protein - Ag13921 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

TMEM173 fusion protein - Ag20363 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human TMEM173, GST-tagged - TMEM173-3281H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Transmembrane Protein 173 (TMEM173) - RPN011Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant Transmembrane Protein 173 (TMEM173) - RPN011Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Transmembrane Protein 173 (TMEM173) - RPN011Ra01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Rat

STING Blocking Peptide - CBP3463 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human

Recombinant Transmembrane Protein 173 (TMEM173) - RPN011Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

TMEM173 / STING - TP308418 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
TMEM173 / STING

STING/TMEM173 Recombinant Protein Antigen - NBP2-38389PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

STING Blocking Peptide - abx162325 from Abbexa

Category Peptide
Species Human
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