Gene Symbol | TMEM173 |
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Entrez Gene | 340061 |
Alt Symbol | ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein 173 |
Other Description | N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner|endoplasmic reticulum IFN stimulator|endoplasmic reticulum interferon stimulator|mitochondrial mediator of IRF3 activation|stimulator of interferon genes protein |
Swissprots | D6RBX0 Q86WV6 A8K3P6 D6RID9 B6EB35 D6RE01 |
Accessions | EAW62098 EAW62099 EAW62100 Q86WV6 AK095896 AK129800 AK290661 BAF83350 AX775913 CAE11656 BC047779 AAH47779 BE548954 BM149879 BM981219 BU731116 FJ222241 ACI46648 HQ448605 ADQ33083 KF430638 AHB86590 XM_005268445 XP_005268502 XM_011537639 XP_011535941 XM_011537640 XP_011535942 NM_001301738 NP_001288667 NM_198282 NP_938023 |
Function | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates d |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited. |
Tissue Specificity | Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages. {ECO:0000269|PubMed:18724357, ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25029335}. |
Top Pathways | RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway |
D. melanogaster Aubergine / Sting peptide - ab19076 from Abcam
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TMEM173 / STING Antibody Blocking Peptide - LS-E30743 from LifeSpan Bioscience
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TMEM173 / STING Antibody Blocking Peptide - LS-E21597 from LifeSpan Bioscience
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TMEM173 / STING Antibody Blocking Peptide - LS-E10295 from LifeSpan Bioscience
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TMEM173 / STING Antibody Blocking Peptide - LS-E10331 from LifeSpan Bioscience
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STING/TMEM173 Peptide - NBP1-77055PEP from Novus Biologicals
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TM173-Antibody-C-term-Blocking-Peptide - BP9807b from Abgent, a WuXi AppTec company
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TM173-Antibody-C-term-Blocking-Peptide - BP9747b from Abgent, a WuXi AppTec company
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MPYS Peptide - GTX85266-PEP from GeneTex
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TMEM173 Blocking Peptide - 33R-2109 from Fitzgerald
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Human TMEM173 Protein - abx069447 from Abbexa
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TMEM173 / STING Control Peptide - AP30565CP-N from Acris Antibodies
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Transmembrane Protein 173 (TMEM173), Human - 20-9542 from ARP American Research Products
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MPYS Peptide - 5269P from ProSci
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TMEM173 fusion protein - Ag13921 from Proteintech Group
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TMEM173 fusion protein - Ag20363 from Proteintech Group
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Recombinant Human TMEM173, GST-tagged - TMEM173-3281H from Creative Biomart
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Recombinant Transmembrane Protein 173 (TMEM173) - RPN011Hu01 from Uscn Life Science Inc.
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Recombinant Transmembrane Protein 173 (TMEM173) - RPN011Mu01 from Uscn Life Science Inc.
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Recombinant Transmembrane Protein 173 (TMEM173) - RPN011Ra01 from Uscn Life Science Inc.
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STING Blocking Peptide - CBP3463 from Cohesion Biosciences
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Recombinant Transmembrane Protein 173 (TMEM173) - RPN011Hu01 from Cloud-clone
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TMEM173 / STING - TP308418 from Acris Antibodies
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STING/TMEM173 Recombinant Protein Antigen - NBP2-38389PEP from Novus Biologicals
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STING Blocking Peptide - abx162325 from Abbexa
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