| Gene Symbol |
USP7
|
| Entrez Gene |
7874
|
| Alt Symbol |
HAUSP, TEF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 7 (herpes virus-associated)
|
| Other Description |
Herpes virus-associated ubiquitin-specific protease|deubiquitinating enzyme 7|herpesvirus-associated ubiquitin-specific protease|ubiquitin carboxyl-terminal hydrolase 7|ubiquitin specific protease 7 (herpes virus-associated)|ubiquitin thioesterase 7|ubiquitin-specific-processing protease 7
|
| Swissprots |
Q93009 B7Z815 H0Y3G8 A6NMY8
|
| Accessions |
CBJ21210 EAW85194 EAW85195 Q93009 AK302481 BAH13721 AK302771 BAH13801 AK302872 BAH13828 AK302912 BAH13841 AK316441 BAH14812 AY376241 AAQ82908 BC166690 AAI66690 Z72499 CAA96580 NM_001286457 NP_001273386 NM_001286458 NP_001273387 NM_003470 NP_003461
|
| Function |
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interact
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23973222}. Cytoplasm. Nucleus, PML body. Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
|
| Tissue Specificity |
Widely expressed. Overexpressed in prostate cancer. {ECO:0000269|PubMed:18716620}.
|
| Top Pathways |
Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection
|
![Western Blot: USP7 Overexpression Lysate (Adult Normal) [NBL1-17671] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for USP7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19357_USP7%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-17671-img0002.jpg)